Recombinant Human BH3 Interacting Domain Death Agonist(BID)

Recombinant Human BH3 Interacting Domain Death Agonist(BID)

参考价：面议
供货周期： 一周
品牌： Prospect Biosystems
规格： 2μg/10μg/1mg
货号： PRO-627
CAS号：
上海希美化学有限公司
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BID Human
BH3 Interacting Domain Death Agonist Human Recombinant
Catalog No. PRO-627

Synonyms:
BH3-interacting domain death agonist, p22 BID, BID, FP497, MGC15319, MGC42355.

Introduction:
BID accessiotn number NP_001187 is a pro-apoptotic Bcl-2 protein having only the BH3 domain. In reaction to apoptotic signaling, BID interacts with another Bcl-2 family of cell death regulators, called Bax, they form a heterodimer resulting to the insertion of Bax into the outer mitochondrial membrane. Bax induces the opening of the mitochondrial voltage-dependent anion channel which lead to the release of cytochrome c and other pro-apoptotic factors from the mitochondria resulting in activation of caspases. BID is a mediator of mitochondrial damage induced by caspase-8 (CASP8). CASP8 cleaves BID, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. The major proteolytic product p15 BID releasea cytochrome c. Isoform 1, Isoform 2 and Isoform 4 induce ice-like proteases and apoptosis while Isoform 3 does not induce apoptosis.

Description:
BID Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 195 amino acids and having a molecular mass of 21.9 kDa.

Source:
Escherichia Coli.

Physical Appearance:
Sterile Filtered colorless solution.

Formulation:
The protein solution contains 20mM Tris-HCl pH-8 & 20% NaCl.

Stability:
BID although stable 4°C for 4 weeks, should be stored desiccated below -18°C.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Please prevent freeze-thaw cycles.

Amino Acid Sequence:
MDCEVNNGSS LRDECITNLL VFGFLQSCSD NSFRRELDAL GHELPVLAPQ WEGYDELQTD GNRSSHSRLG RIEADSESQE
DIIRNIARHL AQVGDSMDRS IPPGLVNGLA LQLRNTSRSE EDRNRDLATA LEQLLQAYPR DMEKEKTMLV LALLLAKKVA SHTPSLLRDV FHTTVNFINQ NLRTYVRSLA RNGMD.

Purity:
Greater than 95.0% as determined by:
(a) Analysis by RP-HPLC.
(b) Analysis by SDS-PAGE.

Usage:
ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

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Recombinant Human BH3 Interacting Domain Death Agonist(BID)由上海希美化学有限公司为您提供，货号PRO-627，规格：2μg/10μg/1mg，CAS号：，如您想了解更多关于Recombinant Human BH3 Interacting Domain Death Agonist(BID)价格、Recombinant Human BH3 Interacting Domain Death Agonist(BID)结构式、批发、用途等信息，欢迎咨询。除供应Recombinant Human BH3 Interacting Domain Death Agonist(BID)外，还可为您提供大鼠BH3结构域凋亡诱导蛋白(Bid)ELISA Kit、小鼠BH3结构域凋亡诱导蛋白(Bid)ELISA Kit等试剂，公司有专业的客户服务团队，是您值得信赖的合作伙伴，上海希美化学客户服务电话，售前、售后均可联系。
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