Mouse Anti Human BH3 Interacting Domain Death Agonist （BID）

Mouse Anti Human BH3 Interacting Domain Death Agonist （BID）

参考价：¥1820
供货周期： 一周
品牌：
规格： 20µg
货号： ANT-353
CAS号：
上海希美化学有限公司
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Catalogue Number ANT-353
Synonyms BH3-interacting domain death agonist, p22 BID, BID, FP497, MGC15319, MGC42355.
Type Mouse Anti Human Monoclonal.
Introduction BID accession number NP_001187 is a pro-apoptotic Bcl-2 protein having only the BH3 domain. In reaction to apoptotic signaling, BID interacts with another Bcl-2 family of cell death regulators, called Bax, they form a heterodimer resulting to the insertion of Bax into the outer mitochondrial membrane. Bax induces the opening of the mitochondrial voltage-dependent anion channel which leads to the release of cytochrome c and other pro-apoptotic factors from the mitochondria resulting in activation of caspases. BID is a mediator of mitochondrial damage induced by caspase-8 (CASP8). CASP8 cleaves BID, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. The major proteolytic product p15 BID releasea cytochrome c. Isoform 1, Isoform 2 and Isoform 4 induce ice-like proteases and apoptosis while Isoform 3 does not induce apoptosis.
Clone P4D3AT.
Immunogen Anti-human BID mAb is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human BID amino acids 1-195 purified from E. coli.
Ig Subclass Mouse IgG1 heavy chain and κ light chain.
Purification Method BID antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
Protein formulation 1mg/ml containing PBS, pH-7.4, & 0.1% Sodium Azide.
Storage Procedures For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.
Stability / Shelf Life 12 months at -20°C. 1 month at 4°C.
Applications BID antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:1,000 ~ 2,000.Recommended starting dilution is 1:1,000.
Usage ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Mouse Anti Human BH3 Interacting Domain Death Agonist （BID）由上海希美化学有限公司为您提供，货号ANT-353，规格：20µg，CAS号：，如您想了解更多关于Mouse Anti Human BH3 Interacting Domain Death Agonist （BID）价格、Mouse Anti Human BH3 Interacting Domain Death Agonist （BID）结构式、批发、用途等信息，欢迎咨询。除供应Mouse Anti Human BH3 Interacting Domain Death Agonist （BID）外，还可为您提供小鼠BH3结构域凋亡诱导蛋白(Bid)ELISA Kit、Recombinant Human BH3 Interacting Domain Death Agonist(BID)等试剂，公司有专业的客户服务团队，是您值得信赖的合作伙伴，上海希美化学客户服务电话，售前、售后均可联系。
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