Recombinant Human Visinin-Like Protein-1(VSNL1)

Recombinant Human Visinin-Like Protein-1(VSNL1)

参考价：面议
供货周期： 一周
品牌： Prospect Biosystems
规格： 2μg/10μg/1mg
货号： PRO-602
CAS号：
上海希美化学有限公司
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VSNL1 Human, His
Visinin-Like Protein-1 Human Recombinant, His Tag
Catalog No. PRO-602

Synonyms:
VISL1, VISL-1, VIS1, VIS-1, VILIP, HLP3, Hippocalcin-like protein 3, VSNL1, VILIP-1, VILIP1, HLP-3, HPCAL3, HUVISL1, Visinin-like protein 1.

Introduction:
VSNL1 is a member of the visinin/recoverin subfamily of neuronal calcium sensor proteins. VILIP1 is strongly expressed in granule cells of the cerebellum where it associates with membranes in a calcium-dependent manner and modulates intracellular signaling pathways of the central nervous system by directly or indirectly regulating the activity of adenylyl cyclase. Changes in cellular expression of VSNL1 were found in hipppocampi of schizophrenics, since more interneurons showed immunoreactivity.
VILIP1 is expressed in pancreatic beta-cells. VILIP1 elevation enhances insulin secretion in cAMP-associated manner. Down-regulation of VILIP-1 decreased cAMP accumulation but increased insulin gene transcription. VILIP-1 interacts with cell membrane and actin-based cytoskeleton. VSNL1 modulates cAMP-accumulation in C6 glioma cells. HLP3 modulates cGMP-accumulation in transfected neural cells and cerebellar granule neurons.

Description:
Visinin-Like Protein-1 Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 201 amino acids and having a molecular mass of 23.4 kDa.
Visinin-Like Protein-1 is fused to His tag at N-Terminus.
The protein‘s amino acid sequence corrssponds toUniProtKB/Swiss-Prot entry P62760.
Visinin-Like Protein-1 is purified by proprietary chromatographic techniques.

Source:
Escherichia Coli.

Physical Appearance:
Sterile Filtered White lyophilized (freeze-dried) powder.

Formulation:
The sterile filtered concentrated (0.5mg/ml) protein solution was lyophilized with 20mM Tris & 20mM NaCl pH-7.5.

Solubility:
Add sterile deionized water to a working concentration of 0.5mg/ml and let the lyophilized pellet dissolve completely.

Stability:
Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/ thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time.

Amino Acid Sequence:
MKHHHHHHAS MGKQNSKLAP EVMEDLVKST EFNEHELKQW YKGFLKDCPS GRLNLEEFQQ LYVKFFPYGD ASKFAQHAFR TFDKNGDGTI DFREFICALS ITSRGSFEQK LNWAFNMYDL DGDGKITRVE MLEIIEAIYK MVGTVIMMKM NEDGLTPEQR VDKIFSKMDK NKDDQITLDE FKEAAKSDPS IVLLLQCDIQK

Purity:
Greater than 95% as determined by SDS-PAGE.

Usage:
ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

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Recombinant Human Visinin-Like Protein-1(VSNL1)由上海希美化学有限公司为您提供，货号PRO-602，规格：2μg/10μg/1mg，CAS号：，如您想了解更多关于Recombinant Human Visinin-Like Protein-1(VSNL1)价格、Recombinant Human Visinin-Like Protein-1(VSNL1)结构式、批发、用途等信息，欢迎咨询。除供应Recombinant Human Visinin-Like Protein-1(VSNL1)外，还可为您提供Recombinant Human CD52、Recombinant Human CD99等试剂，公司有专业的客户服务团队，是您值得信赖的合作伙伴，上海希美化学客户服务电话，售前、售后均可联系。
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