Recombinant Human Heat Shock Factor Binding Protein-1(HSBP-1)

Recombinant Human Heat Shock Factor Binding Protein-1(HSBP-1)

参考价：面议
供货周期： 一周
品牌： Prospect Biosystems
规格： 20μg/100μg/1mg
货号： HSP-001
CAS号：
上海希美化学有限公司
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HSBP1 Human
Heat Shock Factor Binding Protein - 1 Human Recombinant
Catalog No. HSP-001

Synonyms:
NPC-A-13, HSBP1, Heat shock factor-binding protein 1, Nasopharyngeal carcinoma-associated antigen 13, HSF1BP, DKFZp686D1664, DKFZp686O24200.

Introduction:
The heat-shock response is elicited by exposure of cells to thermal and chemical stress and through the activation of HSFs (heat shock factors) results in the elevated expression of heat-shock induced genes. Heat shock factor binding protein-1 (HSBP1), is a 76-amino-acid protein that binds to heat shock factor 1(HSF1), which is a transcription factor involved in the HS response. During HS response, HSF1 undergoes conformational transition from an inert non-DNA-binding monomer to active functional trimers. HSBP1 is nuclear-localized and interacts with the active trimeric state of HSF1 to negatively regulate HSF1 DNA-binding activity. Overexpression of HSBP1 in mammalian cells represses the transactivation activity of HSF1. When overexpressed in C.elegans HSBP1 has severe effects on survival of the animals after thermal and chemical stress consistent with a role of HSBP1 as a negative regulator of heat shock response.

Description:
Recombinant Human HSBP1 produced in E.Coli is a single,non-glycosylated polypeptide chain containing 76 amino acids and having a molecular mass of 8.5 kDa.

Source:
Escherichia Coli.

Physical Appearance:
Sterile filtered colorless solution.

Formulation:
The HSBP1 protein (1mg/ml) solution contains 20mM Tris-HCl buffer pH-7.5, 50mM NaCl, 1mM EDTA and 20% Glycerol.

Stability:
Store at 4°C if entire vial will be used within 2-4 weeks.
Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.

Purity:
Greater than 95.0% as determined by:
(a) Analysis by RP-HPLC.
(b) Analysis by SDS-PAGE.

Sequence:
MAETDPKTVQ DLTSVVQTLL QQMQDKFQTM SDQIIGRIDD MSSRIDDLEK NIADLMTQAG VEELESENKI PATQKS.

Usage:
ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

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Recombinant Human Heat Shock Factor Binding Protein-1(HSBP-1)由上海希美化学有限公司为您提供，货号HSP-001，规格：20μg/100μg/1mg，CAS号：，如您想了解更多关于Recombinant Human Heat Shock Factor Binding Protein-1(HSBP-1)价格、Recombinant Human Heat Shock Factor Binding Protein-1(HSBP-1)结构式、批发、用途等信息，欢迎咨询。除供应Recombinant Human Heat Shock Factor Binding Protein-1(HSBP-1)外，还可为您提供Recombinant Human WNT Inhibitory Factor 1(WIF1)、Recombinant Human Heat Shock Protein 90kDa Beta (GRP94) Member 1(HSP90B1)等试剂，公司有专业的客户服务团队，是您值得信赖的合作伙伴，上海希美化学客户服务电话，售前、售后均可联系。
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