化药新药研发其他>方法开发检测 | First single electron transfer reaction on propargylic chloride in 5-nitroimidazole series through Biotage Initiator耐士科技-上海鑫欣生物科技有限公司

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应用领域	制药/生物制药
检测样本	化药新药研发
检测项目	其他>方法开发
参考标准	GB/T 8****

We report here the first example of an SRN1 reaction on propargylic chloride in heterocyclic series. The reaction of 4-(3-chloroprop-1-ynyl)-1,2-dimethyl-5-nitro-1H-imidazole with nitronate anions led to both the formation of the C-alkylated product through an SRN1 mechanism and the predominant ethylenic compound resulting from nitrous acid elimination on the C-alkylated product. Interestingly, in contrast to our previous works on SRN1 reactivity, no O-alkylated product was observed.

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