其他特殊物质和基团检测 | 使用Biotage微波合成仪进行微波条件下从酰化的2-氨基苯乙酮类化合物进行直接的微波合成得到2-芳基喹诺酮类化合物by耐士科技-上海鑫欣生物科技有限公司

方案摘要

方案下载

应用领域	化药/中药/生物制药
检测样本	其他
检测项目	特殊物质和基团
参考标准	GB/T 8****

End functionalized poly(propylene oxide)s with n-alkyl endgroups are synthesized by anionic ring opening polymerization of propylene oxide (PO) in bulk employing controlled microwave heating in sealed vessels. Different alcohols ranging from n-butanol to n-octadecanol are used as initiator and 2–10 propylene oxide units are added on average. A continuous decrease of internal pressure during the sealed vessel experiment reflects the consumption of PO monomer and the completion of the reaction is confirmed by a drop of the internal pressure to zero. The products are characterized by size exclusion chromatography (SEC), liquid chromatography at critical conditions (LCCC) and liquid adsorption chromatography (LAC). SEC with coupled density and refractive index (RI) detection provides information on the chemical composition along the molar mass distribution. LCCC allows a separation of the individual polymer homologous series according to their end groups. In LAC, the alkyl terminated chains elute later than the non-functional chains and can be separated to the baseline according to the number of repeat units.

方案下载

上一篇耐士科技：使用Biotage Isolera快速纯化液相制备色谱从库拉索芦荟叶皮提取天然的磷酸二酯酶抑制剂by耐士科技

下一篇使用Biotage微波合成仪进行微波条件下的三组分Povarov反应对环戊烯稠环四氢喹啉衍生物进行合成研究by耐士科技

文献贡献者

上海鑫欣生物科技有限公司

银牌会员丨第14年

查看全部资料