化药新药研发其他>方法开发检测 | 通过Biotage Initiator微波反应进行四元稠环以及五元稠环的合成耐士科技-上海鑫欣生物科技有限公司

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应用领域	制药
检测样本	化药新药研发
检测项目	其他>方法开发
参考标准	GB/T 8****

The 4-exo-dig and 5-exo-dig cyclocarbopalladations have been efficiently used to produce molecular complexity in a straightforward manner. Strained 1,2-cyclobutanediols are rapidly obtained under microwave irradiation in high yields. In many cases, the cyclocarbopalladation cascade reaction is associated with a 6 or 8p electrocyclic reaction. During the process of the 5-exo-dig cyclocarbopalladation on benzosuberone derivatives, an aromatic C–H activation leads to vinylic substituted aromatics. Polycyclic skeletons of natural products of the family of Ophiobolin and Aleurodiscal can be prepared in few steps from simple starting material.

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