方案摘要
方案下载应用领域 | 制药/生物制药 |
检测样本 | 化药新药研发 |
检测项目 | 其他>方法开发 |
参考标准 | GB/T 8**** |
A group of novel taxoids, with modifications at C-7, C-10, C-30 and C-14 positions of paclitaxel, was synthesized in order to improve their biological profile by decreasing their affinity with P-glycoprotein (Pgp) and increasing cellular permeability. Most of the new taxoids demonstrated the similar potent cytotoxic activities in MCF-7 human tumor cell line as paclitaxel in vitro. In the permeability assay with monolayers of Caco-2 cells, most of the compounds demonstrated an increased trans-cellular transport in Ato- B direction in comparison with paclitaxel. Among them the compounds T-13, T-15 and T-26 showed the highest permeability, and with efflux ratios better than that of ortataxel. The interaction of the compounds T-13 and T-26 with P-gp was evaluated using Madin-Darby canine kidney (MDCK)-multidrug resistance-1(MDR1) and MDCK-wild-type (WT). The results indicated that T-13 and T-26 were poor substrates for P-gp and possessed inhibiting effects of P-gp mediated efflux. It was thus clear that simultaneous modifications at the C-7, C-10 and C-30 positions of paclitaxel significantly impaired its interactions with P-gp and interfered with P-gp mediated efflux.
优选 KNAUER(德国诺尔)IJM 冲击射流混合系统Customized NanoProducers
型号:Customized NanoProducers优选 KNAUER(德国诺尔)IJM 冲击射流混合系统SingleCore NanoProducer
型号: IJM SingleCore NanoProducer优选 KNAUER(德国诺尔)IJM 冲击射流混合系统 IJM NanoScaler
型号:IJM NanoScaler优选 KNAUER(德国诺尔)IJM 冲击射流混合系统IJM DuoCore NanoProducer
型号:IJM DuoCore NanoProducer耐士科技:使用Biotage Isolera快速纯化液相制备色谱从库拉索芦荟叶皮提取天然的磷酸二酯酶抑制剂by耐士科技
耐士科技:通过Biotage Isolera快速纯化液相制备色谱帮助进行人体尿液中合成大麻素及其代谢产物的定量半定量测定by耐士科技
耐士科技:通过Biotage Isolera快速纯化液相制备色谱帮助进行人体尿液中合成烷基羟基代谢物的定量半定量测定by耐士科技
相关产品
KNAUER(德国诺尔)IJM 冲击射流混合系统Customized NanoProducers
KNAUER(德国诺尔)IJM 冲击射流混合系统IJM DuoCore NanoProducer
KNAUER(德国诺尔)IJM 冲击射流混合系统SingleCore NanoProducer
KNAUER(德国诺尔)IJM 冲击射流混合系统 IJM NanoScaler
KNAUER(德国诺尔) 高压制备液相色谱
KNAUER(德国诺尔)中压制备色谱
KNAUER(德国诺尔)Bio蛋白质层析纯化系统
KNAUER(德国诺尔) SMB模拟移动床色谱
KNAUER(德国诺尔)K-7400S冰点渗透压仪
NMN|β-烟酰胺单核苷酸 |CAS:1094-61-7
KNAUER(德国诺尔)制备柱
关注
拨打电话
留言咨询