方案摘要
方案下载应用领域 | |
检测样本 | |
检测项目 | |
参考标准 |
In this work we reported the generation of D-proline-derived hydroxamic acids as inhibitors of anthrax lethal factor (LF), taking advantage of a pyrrolidine ring as the central scaffold and a hydroxamate group as the Zn2t chelating agent. The introduction of two hydrophobic groups addressing the S10 subsite and a long substrate-binding groove was conceived by overlapping the bioactive conformations of two reported LF inhibitors. Micromolar affinity of compound 38 suggested cis-3-substituted-1-sulfonamido-Dproline hydroxamic acids as a promising class of peptidomimetic inhibitors for developing novel LF inhibitors.
优选 KNAUER(德国诺尔)IJM 冲击射流混合系统Customized NanoProducers
型号:Customized NanoProducers优选 KNAUER(德国诺尔)IJM 冲击射流混合系统SingleCore NanoProducer
型号: IJM SingleCore NanoProducer优选 KNAUER(德国诺尔)IJM 冲击射流混合系统 IJM NanoScaler
型号:IJM NanoScaler优选 KNAUER(德国诺尔)IJM 冲击射流混合系统IJM DuoCore NanoProducer
型号:IJM DuoCore NanoProducer耐士科技:使用Biotage Isolera快速纯化液相制备色谱从库拉索芦荟叶皮提取天然的磷酸二酯酶抑制剂by耐士科技
耐士科技:通过Biotage Isolera快速纯化液相制备色谱帮助进行人体尿液中合成大麻素及其代谢产物的定量半定量测定by耐士科技
耐士科技:通过Biotage Isolera快速纯化液相制备色谱帮助进行人体尿液中合成烷基羟基代谢物的定量半定量测定by耐士科技
相关产品
KNAUER(德国诺尔)IJM 冲击射流混合系统Customized NanoProducers
KNAUER(德国诺尔)IJM 冲击射流混合系统IJM DuoCore NanoProducer
KNAUER(德国诺尔)IJM 冲击射流混合系统SingleCore NanoProducer
KNAUER(德国诺尔)IJM 冲击射流混合系统 IJM NanoScaler
KNAUER(德国诺尔) 高压制备液相色谱
KNAUER(德国诺尔)中压制备色谱
KNAUER(德国诺尔)Bio蛋白质层析纯化系统
KNAUER(德国诺尔) SMB模拟移动床色谱
KNAUER(德国诺尔)K-7400S冰点渗透压仪
NMN|β-烟酰胺单核苷酸 |CAS:1094-61-7
KNAUER(德国诺尔)制备柱
关注
拨打电话
留言咨询