方案摘要
方案下载应用领域 | |
检测样本 | |
检测项目 | |
参考标准 |
Abstract Recently, self-emulsifying drug delivery systems (SEDDS) have been developed as a method to deliver lipophilic drugs. Gelucire® 44/14 is an excipient, from the lauroyl macrogolglycerides family, producing a fine oil-in-water emulsion when introduced into an aqueous phase under gentle agitation as SEDDS, improving thereby solubility of poorly water-soluble drugs and their bioavailability. The aims of this study were to process Gelucire® 44/14 into a powder by cryogenic grinding to produce solid oral dosage forms and to investigate influence of this process on different properties of a formulation made of Gelucire® 44/14 and ketoprofen (90/10). Cryogenic grinding produced Gelucire® 44/14 in a powder form and this process did not change its physical properties, emulsification capacities and dissolution performances of the formulation tested. However, interactions took place between ketoprofen and Gelucire® 44/14 with a decrease of the melting peak and a reduction of the droplet size of the formed emulsion. The influence of drug–Gelucire® 44/14 interactions must be investigated case by case in any formulations. © 2004 Elsevier B.V. All rights reserved. Keywords: Lipid formulations; Self-emulsifying systems; Gelucire® 44/14; Ketoprofen; Bioavailability; Cryogenic grinding
Hot consolidation of Cu–Li powder alloys
相关产品
BioDrop 微量比色皿
BioDrop TOUCH 超微量分光光度计
BioDrop μLITE 超微量分光光度计
BioDrop DUO 多功能超微量分光光度计
高通量动植物组织研磨机
SpectroMill®-TS单研磨罐高能量球磨机
SpectroMill® II双研磨罐高能量球磨机
冷冻研磨系统
HT Mini高能量台式动植物组织研磨机
HT Homogenizer高通量动植物组织研磨机
Talboys 多点磁力搅拌器
Talboys 数显型5000敞开式摇床
Talboys Professional 3500恒温培养摇床
Talboys 数显型旋涡混合器
Talboys 数显型多管式旋涡混合器
关注
拨打电话
留言咨询