Anti-Beta-arrestin 1抗体,β-抑制蛋白1抗体

Anti-Beta-arrestin 1抗体,β-抑制蛋白1抗体产品介绍：Beta Arrestin 1 is a member of a family of proteins that are widely expressed but especially abundant in the central nervous system. Serving as an adaptor or scaffold molecule, beta Arrestin 1 is essential for mitogenic signaling. It mediates agonist dependent desensitization and internalization of G protein coupled receptors (GPCRs, e.g., beta 2 adrenergic receptor). After binding to their ligand and interacting with heterotrimeric G proteins, GPCRs are phosphorylated by G protein receptor kinases (GRKs) on serine residues. Beta Arrestin 1 has important roles in the cytoplasm and at the plasma membrane in the desensitization and internalization of G protein coupled receptors (GPCRs) and is increasingly appreciated to play an important role in the endocytosis and signaling of GPCRs. Beta Arrestin 1 in the cytosol is phosphorylated by ERK1 and 2 on serine 412 in a negative feedback mechanism and binds to the phosphorylated receptors at the plasma membrane. Serine 412 is then dephosphorylated and the GPCRs are internalized, leading to activation of the Ras, Raf, ERK1 and 2 signaling pathway.

产品经无数次市场验证，若出现质量问题可无条件退换货服务。

抗体种属：兔抗单克隆抗体鼠抗单克隆抗体，抗体的浓度为1mg/ml。

规    格：0.1ml和0.2ml 

抗体的相关标记：HRP,Biotin,Gold,RBITC,AP,FITC,Cy3,Cy5,Cy5.5,Cy7,PE,PE-Cy3,PE-Cy5,PE-Cy5.5,PE-Cy7,APC,Alexa Fluor 350,Alexa Fluor 488,Alexa Fluor 555,Alexa Fluor 647

抗体的交叉反应：人，小鼠，大鼠，鸡 ，狗，猪，羊，牛，兔等......

抗体的交叉反应：人，小鼠，大鼠，鸡 ，狗，猪，羊，牛，兔等......

应    用：可以用于做石蜡切片免疫组化，冰冻切片免疫组化，Elisa，WB，免疫荧光等实验。

（公司备有抗体及以下抗体做免疫组化与WB所需的二抗）

Anti-Beta-arrestin 1抗体,β-抑制蛋白1抗体的应用稀释：

1、Western Blotting (starting dilution 1:200, dilution range1:100-1:1000)2、Immunoprecipitation [1-2 μg per 100-500 μg of total protein(1 ml ofcell lysate)]

3、Immunofluorescence (starting dilution 1:50, dilution range 1:50-1:500)

4、ELISA (starting dilution 1:30, dilution range 1:30-1:3000)

5、Immunohistochemistry(including paraffin-embedded sections) (starting dilution 1:50

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Anti-Beta-arrestin 1抗体,β-抑制蛋白1抗体广泛应用于IHC、WB、 IF、IP、ELISA，质量保证，无效免费退换，另外本公司生产经营各种标记二抗、免疫印迹常用试剂、免疫组化常用试剂，欢迎来电来邮咨询！