英文名称 Anti-EDA/Ectodermal dysplasia protein
中文名称 外胚层发育不良蛋白1抗体
别 名 Ectodermal dysplasia 1, anhidrotic; Ectodermal dysplasia protein; Ectodermal dysplasia, anhidrotic (hypohydrotic); Ectodysplasin A; Ectodysplasin A, membrane form; Ectodysplasin A, secreted form; ECTODYSPLASIN A1 ISOFORM; ECTODYSPLASIN A2 ISOFORM; ECTODYSPLASIN; Ectodysplasin-A; ED1 A1; ED1 A2; ED1; ED1 GENE; Eda A1; Eda A2; eda; EDA protein; EDA protein homolog; EDA_HUMAN; EDA1; EDA1 GENE; EDA2; HED; ODT1; Oligodontia 1; secreted form; STHAGX1; Ta; Tabby; Tabby protein; X linked anhidroitic ectodermal dysplasia protein; XHED; XLHED.
外胚层发育不良蛋白1抗体浓 度 1mg/1ml
规 格 0.2ml/200μg
抗体来源 Rabbit
克隆类型 polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Cow, Rabbit, Sheep
产品类型 一抗
研究领域 细胞生物 发育生物学 信号转导 干细胞 细胞膜蛋白
蛋白分子量 predicted molecular weight: 24/41kDa
性 状 Lyophilized or Liquid
免 疫 原 KLH conjugated synthetic peptide derived from human Ectodysplasin-A, membrane form/secreted form
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 ICC=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 Affected males of X-linked anhidrotic ectodermal dysplasia show hypotrichosis, abnormal teeth and absent sweat glands. Some of the patients reported by Halperin and Curtis showed mental defect also, but this is not an invariable feature. Ectodysplasin A (EDA) is a trimeric type II membrane protein that co-localizes with cytoskeletal structures at the lateral and apical surfaces of cells. EDA is expressed in hair follicles and in the epidermis of adult skin. The sequence of the longest isoform includes an interrupted collagenous domain of 19 Gly-X-Y repeats and a motif conserved in the tumor necrosis factor (TNF)-related ligand family. EDA is a member of the TNF-related ligand family involved in the early epithelial-mesenchymal interaction that regulates ectodermal appendage formation. Similar to other members of collagenous membrane proteins and members of TNF-related ligands, EDA is a type II membrane protein which forms trimers.
Function : Seems to be involved in epithelial-mesenchymal signaling during morphogenesis of ectodermal organs. Isoform 1 binds only to the receptor EDAR, while isoform 3 binds exclusively to the receptor XEDAR.
Subunit : Homotrimer. The homotrimers may then dimerize and form higher-order oligomers.
Subcellular Location : Secreted and Cell membrane.
Tissue Specificity : Not abundant; expressed in specific cell types of ectodermal (but not mesodermal) origin of keratinocytes, hair follicles, sweat glands. Also in adult heart, liver, muscle, pancreas, prostate, fetal liver, uterus, small intestine and umbilical chord.
Post-translational modifications : N-glycosylated.
Processing by furin produces a secreted form.
DISEASE : Defects in EDA are the cause of ectodermal dysplasia type 1 (ED1) [MIM:305100]; also known as Christ-Siemens-Touraine syndrome or X-linked hypohidrotic ectodermal dysplasia (XLHED). Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. ED1 is a disease characterized by sparse hair (atrichosis or hypotrichosis), abnormal or missing teeth and the inability to sweat due to the absence of sweat glands. ED1 is the most common form of over 150 clinically distinct ectodermal dysplasias.
Defects in EDA are the cause of tooth agenesis selective X-linked type 1 (STHAGX1) [MIM:313500]. A form of selective tooth agenesis, a common anomaly characterized by the congenital absence of one or more teeth. Selective tooth agenesis without associated systemic disorders has sometimes been divided into 2 types: oligodontia, defined as agenesis of 6 or more permanent teeth, and hypodontia, defined as agenesis of less than 6 teeth. The number in both cases does not include absence of third molars (wisdom teeth).
Similarity : Belongs to the tumor necrosis factor family.
Contains 1 collagen-like domain.
Database links : UniProtKB/Swiss-Prot: Q92838.2
半个多世纪以来，抗体一直作为常用的研究工具，因此对其使用和储存已有丰富的经验。这些经验让人们知道如何对抗体进行操作，由于抗体的稳定性好，使用并不困难。抗体较其他蛋白不易变性，易于存放、纯化和标记。蛋白G和蛋白A等抗体结合蛋白的发现使得这项工作更具可行性。
选择合适的抗体对免疫化学技术的成功极为重要。没有任何一种来源的抗体能够满足本书所述的各种方法的要求。为了研究某一重要的抗原，应选用具有不同特性的多种抗体。在没有一套良好特性的抗体可用于研究机体中每一种蛋白之前，选择及制备适合各种技术要求的抗体非常必要。
J00363 人环磷酸腺苷(cAMP)ELISA试剂盒 Human cyclic adenosine monophosphate，cAMP ELISA Kit 96T/48T
J00364 人乳酸脱氢酶(LDH)ELISA试剂盒 Human Lactate Dehydrogenase，LDH ELISA Kit 96T/48T
J00365 人抑肽酶(AP)ELISA试剂盒 Human Aprotinin，AP ELISA Kit 96T/48T
J00366 人基质金属蛋白酶11(MMP11)ELISA试剂盒 Human matrix metalloproteinase 11，MMP11 ELISA Kit 96T/48T
J00367 人磷酯酶C(PLC)ELISA试剂盒 Human Phospholipase C，PLC ELISA Kit 96T/48T
J00368 人丝氨酸蛋白酶(PRSS)ELISA试剂盒 Human serine protease，PRSS ELISA Kit 96T/48T
J00369 人尿激酶(UK)ELISA试剂盒 Human urokinase，UK ELISA Kit 96T/48T
J00370 人弹性蛋白酶(Elastase)ELISA试剂盒 Human Elastase ELISA Kit 96T/48T
J00371 人白细胞弹性蛋白酶(HLE)ELISA试剂盒 Human leukocyte exastase，HLE ELISA Kit 96T/48T
J00372 人α淀粉酶(AMS/AMY)ELISA试剂盒 Human α-Amylase，AMS/AMY ELISA Kit 96T/48T
J00373 人碱性磷酸酶(ALP)ELISA试剂盒 Human alkaline phosphatase，ALP ELISA Kit 96T/48T
J00374 人胶原酶II(Collagenase II)ELISA试剂盒 Human Collagenase Type II ELISA Kit 96T/48T
J00375 人乙酰胆碱酯酶(AChE)ELISA试剂盒 Human Acetylcholinesterase，AChE ELISA Kit 96T/48T
J00376 人葡萄糖氧化酶(GOD)ELISA试剂盒 Human glucose oxidase，GOD ELISA Kit 96T/48T
J00377 人透明质酸酶(HAase)ELISA试剂盒 Human Hyaluronidase，HAase ELISA Kit 96T/48T
J00378 人酸性磷酸酶(ACP)ELISA试剂盒 Human Acid Phosphatase，ACP ELISA Kit 96T/48T
J00379 人β葡萄糖醛酸苷酶(βGD)ELISA试剂盒 Human β-glucuronidase，βGD ELISA Kit 96T/48T
J00380 人β葡糖苷酶(β-glucosidase)ELISA试剂盒 Human β-glucosidase ELISA Kit 96T/48T
J00381 人β内酰胺酶(β-lactamase)ELISA试剂盒 Human β-lactamase ELISA Kit 96T/48T
J00382 人β甘露糖苷酶(β Manase)ELISA试剂盒 Human α mannosidase，α Manase ELISA Kit 96T/48T
J00383 人肌酸激酶(CK)ELISA试剂盒 Human Creatine Kinase，CK ELISA Kit 96T/48T
J00384 人蛋白激酶C(PKC)ELISA试剂盒 Human protein kinase C，PKC ELISA Kit 96T/48T
J00385 人醛缩酶(ALD)ELISA试剂盒 Human Aldolase，ALD ELISA Kit 96T/48T
J00386 人L-乳酸脱氢酶(L-LDH)ELISA试剂盒 Human L-Lactate Dehydrogenase，L-LDH ELISA Kit 96T/48T
J00387 人激肽释放酶8(KLK 8)ELISA试剂盒 Human urokinase-type plasminogen activator，uPA/PLAU ELISA Kit 96T/48T
J00388 人激肽释放酶6(KLK 6)ELISA试剂盒 Human Kallikrein 6，KLK 6 ELISA Kit 96T/48T
J00389 人溶菌酶(LZM)ELISA试剂盒 Human Lysozyme，LZM ELISA Kit 96T/48T
J00390 人胃蛋白酶(PP)ELISA试剂盒 Human Pepsin，PP ELISA Kit 96T/48T
J00391 人碳酸酐酶2(CA-2)ELISA试剂盒 Human carbonic anhydrase 2，CA-2 ELISA Kit 96T/48T
J00392 人颗粒酶B(Gzms-B)ELISA试剂盒 Human granzymes B，Gzms-B ELISA Kit 96T/48T
J00393 人颗粒酶A(Gzms-A)ELISA试剂盒 Human granzymes A，Gzms-A ELISA Kit 96T/48T
J00394 人抗酒石酸酸性磷酸酶5b(TRACP-5b)ELISA试剂盒 Human tartrate-resistant acid phosphatase 5b，TRACP-5b ELISA Kit 96T/48T
J00395 人丙酮酸激酶M2型同工酶(M2-PK)ELISA试剂盒 Human Pyruvate Kinase，M2-PK ELISA Kit 96T/48T
J00396 人诱导型一氧化氮合成酶(iNOS)ELISA试剂盒 Human inducible nitric oxide synthase，iNOS ELISA Kit 96T/48T
J00397 人磷脂酶A2(PL-A2)ELISA试剂盒 Human Phospholipidase A2，PL-A2 ELISA Kit 96T/48T
J00398 人一氧化氮合成酶(NOS)ELISA试剂盒 Human nitric oxide synthase，NOS ELISA Kit 96T/48T
J00399 人端粒酶(TE)ELISA试剂盒 Human telomerase，TE ELISA Kit 96T/48T
J00400 人基质金属蛋白酶9/明胶酶B(MMP-9/Gelatinase B)ELISA试剂盒 Human matrix metalloproteinase 9/Gelatinase B，MMP-9 ELISA Kit 96T/48T
J00401 人肌酸激酶同工酶MB(CK-MB)ELISA试剂盒 Human Creatine Kinase MB isoenzyme，CK-MB ELISA Kit 96T/48T
J00402 人前列腺酸性磷酸酶(PAP)ELISA试剂盒 Human Prostatic Acid Phosphatase，PAP ELISA Kit 96T/48T
J00403 人血管紧张素转化酶(ACE)ELISA试剂盒 Human Angiotensin converting enzyme，ACE ELISA Kit 96T/48T
J00404 人尿蛋白(UP)ELISA试剂盒 Human Proteinuria，UP ELISA Kit 96T/48T
J00405 人水通道蛋白2(AQP-2)ELISA试剂盒 Human Aquaporin 2，AQP-2 ELISA Kit 96T/48T
J00406 人肌钙蛋白T(Tn-T)ELISA试剂盒 Human Troponin T，Tn-T ELISA Kit 96T/48T
J00407 人血管内皮抑素抗体(ES-Ab)ELISA试剂盒 Human anti-Endostatin antibody，ES-Ab ELISA Kit 96T/48T
J00408 人热休克蛋白27(HSP-27)ELISA试剂盒 Human heat shock protein 27，HSP-27 ELISA Kit 96T/48T
J00409 人血管抑素/血管稳定蛋白(ANG)ELISA试剂盒 Human angiostatin，ANG ELISA Kit 96T/48T
J00410 人心型脂肪酸结合蛋白(h-FABP)ELISA试剂盒 Human heart fatty acid binding protein，h-FABP ELISA Kit 96T/48T
J00411 人血管舒缓激肽(BK)ELISA试剂盒 Human Bradykinin，BK ELISA Kit 96T/48T
J00412 人肌球蛋白轻链(MLC)ELISA试剂盒 Human Myosin light Chain，MLC ELISA Kit 96T/48T
J00413 人α-辅肌动蛋白3(ACTN-3)ELISA试剂盒 Human α-Actinin 3，ACTN-3 ELISA Kit 96T/48T
J00414 人超敏C反应蛋白(hs-CRP)ELISA试剂盒 Human high sensitivity C-Reactive Protein，hs-CRP ELISA Kit 96T/48T
J00415 人肌钙蛋白Ⅰ(Tn-Ⅰ)ELISA试剂盒 Human Troponin Ⅰ，Tn-Ⅰ ELISA Kit 96T/48T
J00416 人血清淀粉样蛋白A(SAA)ELISA试剂盒 Human Serum amyloid A，SAA ELISA Kit 96T/48T
J00417 人热休克蛋白60(Hsp-60)ELISA试剂盒 Human Heat Shock Protein 60，HSP-60 ELISA Kit 96T/48T
J00418 人热休克蛋白90(HSP-90)ELISA试剂盒 Human Heat Shock Protein 90，HSP-90 ELISA Kit 96T/48T
J00419 人热休克蛋白70(HSP-70)ELISA试剂盒 外胚层发育不良蛋白1抗体Human Heat Shock Protein 70，HSP-70 ELISA Kit 96T/48T
J00420 人热休克蛋白40(HSP-40)ELISA试剂盒 Human Heat Shock Protein 40，HSP-40 ELISA Kit 96T/48T
J00421 人热休克蛋白20(HSP-20)ELISA试剂盒 Human Heat Shock Protein 20，HSP-20 ELISA Kit 96T/48T
J00422 人肌球蛋白(MYS)ELISA试剂盒 Human Myosin，MYS ELISA Kit 96T/48T
J00423 人C反应蛋白(CRP)ELISA试剂盒 Human C-Reactive Protein，CRP ELISA Kit 96T/48T
J00424 人醛固酮(ALD)ELISA试剂盒 human aldosterone，ALD ELISA Kit 96T/48T
J00425 人肌红蛋白(MYO/MB)ELISA试剂盒 Human Myoglobin，MYO/MB ELISA Kit 96T/48T
J00426 人心肌肌钙蛋白Ⅰ(cTn-Ⅰ)ELISA试剂盒 Human cardiac troponin Ⅰ，cTn-ⅠELISA Kit 96T/48T
更多外胚层发育不良蛋白1抗体价格、批发价、品牌、厂家及抗体详细说明书，都可以免费咨询及索取。
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