英文名称 Anti-EYA2
中文名称 眼睛发育缺失蛋白EYA2抗体
别 名 EAB 1; EAB1; EYA 2; EYA2; EYA2_HUMAN; eyes absent 2 homolog (Drosophila); Eyes absent homolog 2; Translation of this uORF probably lowers the translation efficiency of EYA2.
眼睛发育缺失蛋白EYA2抗体浓 度 1mg/1ml
规 格 0.2ml/200μg
抗体来源 Rabbit
克隆类型 polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep
产品类型 一抗
研究领域 细胞生物 发育生物学 神经生物学
蛋白分子量 predicted molecular weight: 59kDa
性 状 Lyophilized or Liquid
免 疫 原 KLH conjugated synthetic peptide derived from human EYA2
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 A gene on chromosome 20q13.1 encodes Eya2 (eyes absent). EYA2 is one of four members of the eyes absent family. A 271 amino acid domain at the carboxy-terminal is highly conserved amongst the members of the eyes absent family, while the PST (proline-serive-threonin)-rich amino-terminal is highly divergent. EYA2 is expressed relatively late in development in the cytoplasm of extensor tendons and ligaments of the phalangeal elements of the limb, cranial placodes, branchial arches, central nervous system, and the developing eye. Pax3 induces the expression of Eya2 in a cascade that is necessary and sufficient for myogenesis. EYA2, like EYA1, acts as a transcriptional activator in connective tissue patterning through its PST domain, which functions as a transactivation domain. EYA2 is translocated to the nucleus by Six proteins, which interact through their domain and homeodomain with EYA2. EYA2 carboxy-terminal interacts with the G Alpha z and G Alphai 2 proteins. This interaction prevents Six proteins from translocating EYA2 to the nucleus.
Function : Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Coactivates SIX1. Seems to coactivate SIX2, SIX4 and SIX5. Together with SIX1 and DACH2 seem to be involved in myogenesis. May be involved in development of the eye. Interaction with GNAZ and GNAI2 prevents nuclear translocation and transcriptional activity.
Subunit : Interacts with GNAZ and GNAI2. Interacts with DACH2 and SIX1, and probably with SIX2, SIX4 and SIX5. Interacts with CAPN8 (By similarity).
Subcellular Location : Cytoplasm. Nucleus.
Tissue Specificity : Highest expression in muscle with lower levels in kidney, placenta, pancreas, brain and heart.
Similarity : Belongs to the HAD-like hydrolase superfamily. EYA family.
Database links : UniProtKB/Swiss-Prot: O00167.2
半个多世纪以来，抗体一直作为常用的研究工具，因此对其使用和储存已有丰富的经验。这些经验让人们知道如何对抗体进行操作，由于抗体的稳定性好，使用并不困难。抗体较其他蛋白不易变性，易于存放、纯化和标记。蛋白G和蛋白A等抗体结合蛋白的发现使得这项工作更具可行性。
选择合适的抗体对免疫化学技术的成功极为重要。没有任何一种来源的抗体能够满足本书所述的各种方法的要求。为了研究某一重要的抗原，应选用具有不同特性的多种抗体。在没有一套良好特性的抗体可用于研究机体中每一种蛋白之前，选择及制备适合各种技术要求的抗体非常必要。
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J01340 人脂磷壁酸(LTA)ELISA试剂盒 Human lipoteichoic acids,LTA ELISA Kit 96T/48T
J01341 人乙胺碘呋酮(AD)ELISA试剂盒 Human amiodarone,AD ELISA Kit 96T/48T
J01342 人唾液酸(SA)ELISA试剂盒 Human Sialic acid,SA ELISA Kit 96T/48T
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J01347 人吖啶橙(AO)ELISA试剂盒 Human Acrine Orange,AO ELISA Kit 96T/48T
J01348 人甲胺喋呤(MTX)ELISA试剂盒 Human methotrexate,MTX ELISA Kit 96T/48T
J01349 人对氨基苯甲酸(PABA)ELISA试剂盒 Human para-aminobenzoic acid,PABA ELISA Kit 96T/48T
J01350 人苯丙氨酸(LPA)ELISA试剂盒 Human L-phenylalanine,LPA ELISA Kit 96T/48T
J01351 人免疫核糖核酸(Irna)ELISA试剂盒 Human Immune RNA,Irna ELISA Kit 96T/48T
J01352 人β内酰胺酶抑制剂(BLI)ELISA试剂盒 Human β-Lactamase inhibitors,BLI ELISA Kit 96T/48T
J01353 人α半乳糖基抗体(Gal)ELISA试剂盒 Human α-galactoyl,Gal ELISA Kit 96T/48T
J01354 人αN已酰氨基葡糖苷酶(αNAG)ELISA试剂盒 Human αN-acetylglucosaminidase,αNAG ELISA Kit 96T/48T
J01355 人α2纤溶酶抑制物(α2-PI)ELISA试剂盒 Human α2-plasmin inhititor,α2-PI ELISA Kit 96T/48T
J01356 人烟酰胺腺嘌呤二核苷酸磷酸(NADPH)ELISA试剂盒 人高香草酸(HVA) ELISA Kit 96T/48T
J01357 人钙粘蛋白相关的神经受体1(CNR-1)ELISA试剂盒 Human cadherln-related neuronal receptor1,CNR-1 ELISA Kit 96T/48T
J01358 人毛细血管扩张性共济失调突变基因(ATM)ELISA试剂盒 Human Ataxia telangiectasia mutated,ATM ELISA Kit 96T/48T
J01359 人芳香烃受体(AhR)ELISA试剂盒 Human aryl hydrocarbon receptor,AhR ELISA Kit 96T/48T
J01360 人特异性巨噬细胞武装因子(SMAF)ELISA试剂盒 Human Specifie Macrophage Arming Paetot,SMAF ELISA Kit 96T/48T
J01361 人促有丝分裂因子(MF/MPF)ELISA试剂盒 Human maturation promoting factor,MF/MPF ELISA Kit 96T/48T
J01362 人转录因子抗体-1(ATF-1)ELISA试剂盒 Human activating transcription factor-1,ATF-1 ELISA Kit 96T/48T
J01363 人抗鼠抗体(HAMA)ELISA试剂盒 Human antimous antibody,HAMA ELISA 96T/48T
J01364 人钙离子通道抗体(VGCC)ELISA试剂盒 Human voltage-gated calcium channel,VGCC ELISA Kit 96T/48T
J01365 人溴脱氧核苷尿嘧啶(BrdU)ELISA试剂盒 Human Bromodeoxyuridine,BrdU ELISA Kit 96T/48T
J01366 人纤维母细胞表面抗原(FSP)ELISA试剂盒 Human Fibroblast surface protein,FSP ELISA Kit 96T/48T
J01367 人分泌性白细胞蛋白酶抑制因子(SLPI)ELISA试剂盒 Human secretory leukocyte protease inhibitor,SLPI ELISA Kit 96T/48T
J01368 人阿黑皮素原(POMC)ELISA试剂盒 Human pro-opiomelanocortin,POMC ELISA Kit 96T/48T
J01369 人不对称二甲基精氨酸(ADMA)ELISA试剂盒 Human asymmetrical dimethylarginine,ADMA ELISA Kit 96T/48T
J01370 人血清素/血清胺(ST)ELISA试剂盒 Human Serotonin,ST ELISA Kit 96T/48T
J01371 人细胞毒素(CTX)ELISA试剂盒 Human cytotoxin,CTX ELISA Kit 96T/48T
J01372 人α突触核蛋白(α-SYN)ELISA试剂盒 Human α-Synuclein,α-SYN ELISA Kit 96T/48T
J01373 人糖链抗原19-9(CA19-9)ELISA试剂盒 Human Carbohydrate antigen19-9,CA19-9 ELISA Kit 96T/48T
J01374 人水蛭素(HRD)ELISA试剂盒 Human Hirudin,HRD ELISA Kit 96T/48T
J01375 人他克莫司(FK506)ELISA试剂盒 Human Tacrolimus-FK506 ELISA Kit 96T/48T
J01376 人上皮特异性抗原(ESA)ELISA试剂盒 Human epithelial specific antigen,ESA ELISA Kit 96T/48T
J01377 人上皮膜抗原(EMA)ELISA试剂盒 Human Epithelial membrane antigen,EMA ELISA Kit 96T/48T
J01378 人OJ抗体/抗异亮氨酰tRNA合成酶抗体(OJ/IleRS)ELISA试剂盒 Human anti-OJ-antibody，OJ/IleRS ELISA Kit 96T/48T
J01379 人抗着丝点抗体(ACA/CENP)ELISA试剂盒 Human Anticentromere Antibody,ACA/CENP ELISA Kit 96T/48T
J01380 人肌细胞生成素(MYOG)ELISA试剂盒 Human myogenin,MYOG ELISA Kit 96T/48T
J01381 人A组链球菌菌壁多糖抗体(ASP)ELISA试剂盒 Human antibody to group A streptococcal polysaccharide,ASP ELISA Kit 96T/48T
J01382 人活化蛋白C抵抗素(APCR)ELISA试剂盒 Human activated protein C resistance,APCR ELISA Kit 96T/48T
J01383 人N端外显肽(Ext-N)ELISA试剂盒 Human N-terminal extein,Ext-N ELISA Kit 96T/48T
J01384 人分泌成分(SC)ELISA试剂盒 Human secretory component,SC ELISA Kit 96T/48T
J01385 人蛋白聚糖(PG)ELISA试剂盒 Human Proteoglycan,PG ELISA Kit 96T/48T
J01386 人吡啶酚(PYD)ELISA试剂盒 Human Pyridinoline,PYD ELISA Kit 96T/48T
J01387 人上皮中性粒细胞活化肽78(ENA-78/CXCL5)ELISA试剂盒 Human Epithelial neutrophil activating peptide 78,ENA-78 ELISA Kit 96T/48T
J01388 人鸟苷酸交换因子(GEF)ELISA试剂盒 Human Guanine Exchange Factor,GEF ELISA Kit 96T/48T
J01389 人维生素D受体(VD R)ELISA试剂盒 Human Vitamin D Receptor,VD R ELISA Kit 96T/48T
J01390 人毒性休克综合征毒素1(TSST-1)ELISA试剂盒 Human toxic shock syndrome toxin,TSST-1 ELISA Kit 96T/48T
J01391 人金葡菌肠毒素(SE)ELISA试剂盒 眼睛发育缺失蛋白EYA2抗体Human staphylococcus aureus enterotoxins,SE ELISA Kit 96T/48T
J01392 人β细胞素(BTC) ELISA试剂盒 Human beta cellulin,BTC ELISA Kit 96T/48T
J01393 人胎盘核糖核酸抑止剂(HPRI)ELISA试剂盒 Human placental ribonuclease inhibitor,HPRI ELISA Kit 96T/48T
J01394 人胎盘催乳素(HPL)ELISA试剂盒 Human placenta lactogen,HPL ELISA Kit 96T/48T
J01395 人胎儿血红蛋白(HBF)ELISA试剂盒 Human anti-cytomegalovirus IgM antibody,anti-CMV IgM ELISA Kit 96T/48T
J01396 人抗巨细胞病毒抗体IgM(anti-CMV IgM)ELISA试剂盒 Human anti-cytomegalovirus IgM antibody,anti-CMV IgM ELISA Kit 96T/48T
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