英文名称 Anti-ELMO2
中文名称 吞噬细胞运动蛋白2抗体
别 名 CED 12; Ced 12 homolog 2; CED 12 homolog A; CED 12A; CED-12; ced-12 homolog 2; CED12; CED12 homolog A; CED12A; ELMO 2; ELMO-2; ELMO2; ELMO2_HUMAN; Engulfment and cell motility 2 (ced 12 homolog, C. elegans); Engulfment and cell motility 2; Engulfment and cell motility protein 2; FLJ11656; hCED 12A; hCED-12A; hCED12A; KIAA1834; PH domain protein CED12A; Protein ced 12 homolog A; Protein ced-12 homolog A.
吞噬细胞运动蛋白2抗体浓 度 1mg/1ml
规 格 0.2ml/200μg
抗体来源 Rabbit
克隆类型 polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep
产品类型 一抗
研究领域 细胞生物 信号转导 细胞凋亡
蛋白分子量 predicted molecular weight: 83kDa
性 状 Lyophilized or Liquid
免 疫 原 KLH conjugated synthetic peptide derived from human ELMO2
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 Elmo (engulfment and cell motility) proteins share similarity to C. elegans CED-12. The C. elegans genes ced-2, ced-5, ced-10, and ced-12 and their mammalian homologs CRKII, DOCK1, RAC1 and ELMO mediate cytoskeletal rearrangements during phagocytosis of apoptotic cells and cell motility. Elmo1 associates with DOCK 180 and may influence phagocytosis and effect cell shape changes. Src family kinase mediated tyrosine phosphorylation of ELMO1 influences signaling through Elmo1/Crk/DOCK 180 pathways. Elmo2 interacts directly with Rho G in a GTP-dependent manner and forms a ternary complex with DOCK 180 to induce activation of Rac 1. The RhoG-Elmo2-DOCK 180 pathway is required for activation of Rac 1 and cell spreading mediated by integrin, as well as for neurite outgrowth induced by nerve growth factor. Elmo3 acts in assocation with DOCK180 and Crk II and may be required in complex with DOCK180 to activate Rac/Rho small GTPases.
Function : Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in assocation with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.
Subunit : Interacts with the SH3-domain of DOCK1 via its SH3-binding site. Probably part of a complex with DOCK1 and RAC1. Probably part of a complex with DOCK1 and CRK isoform CRK-II. Interacts with ARHGEF16, DOCK4 and EPHA2; mediates activation of RAC1 by EPHA2.
Subcellular Location : Cytoplasm. Cytoplasm; cytosol. Membrane.
Tissue Specificity : Widely expressed, with a higher expression in skeletal muscle, kidney and placenta.
Similarity : Contains 1 ELMO domain.
Contains 1 PH domain.
Database links : UniProtKB/Swiss-Prot: Q96JJ3.2
半个多世纪以来，抗体一直作为常用的研究工具，因此对其使用和储存已有丰富的经验。这些经验让人们知道如何对抗体进行操作，由于抗体的稳定性好，使用并不困难。抗体较其他蛋白不易变性，易于存放、纯化和标记。蛋白G和蛋白A等抗体结合蛋白的发现使得这项工作更具可行性。
选择合适的抗体对免疫化学技术的成功极为重要。没有任何一种来源的抗体能够满足本书所述的各种方法的要求。为了研究某一重要的抗原，应选用具有不同特性的多种抗体。在没有一套良好特性的抗体可用于研究机体中每一种蛋白之前，选择及制备适合各种技术要求的抗体非常必要。
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J01513 人晚期糖基化终末产物受体(RAGE/AGER)ELISA试剂盒 Human Receptor for advanced glycation end products, RAGE/AGER ELISA Kit 96T/48T
J01514 人胰多肽(PP)ELISA试剂盒 Human Pancreatic Polypeptide,PP ELISA Kit 96T/48T
J01515 人胰岛素自身抗体(IAA)ELISA试剂盒 Human insulin autoantibodies,IAA ELISA Kit 96T/48T
J01516 人谷氨酸脱羧酶(GAD)ELISA试剂盒 Human glutamic acid decarboxylase,GAD ELISA Kit 96T/48T
J01517 人胸腺五肽(TP-5)ELISA试剂盒 Human Thymopentin,TP-5 ELISA Kit 96T/48T
J01518 人未磷酸化类胰岛素生长因子结合蛋白-1ELISA试剂盒 Human Non-Phosphorylated Insulin-like growth factor binding protein 1 ELISA Kit 96T/48T
J01519 人甲状旁腺激素样蛋白(PLP)ELISA试剂盒 Human parathyroid hormone-like protein,PLP ELISA Kit 96T/48T
J01520 人葡萄糖依赖性胰岛素释放多肽(GIP)ELISA试剂盒 Human Glucose dependent insulin releasing polypeptide,GIP ELISA Kit 96T/48T
J01521 人胰岛素原(PI)ELISA试剂盒 Human Proinsulin,PI ELISA Kit 96T/48T
J01522 人胰岛素受体β(ISR-β)ELISA试剂盒 Human Insulin Receptor β,ISR-β ELISA Kit 96T/48T
J01523 人糖化血红蛋白A1c(GHbA1c)ELISA试剂盒 Human Glycated hemoglobin A1c,GHbA1c ELISA Kit 96T/48T
J01524 人胰高血糖素样肽1(GLP-1)ELISA试剂盒 Human ghcagons-like pepfide 1,GLP-1 ELISA Kit 96T/48T
J01525 人甲状腺刺激免疫球蛋白(TSI)ELISA试剂盒 human thyroid stimulating immunoglobulin,TSI ELISA Kit 96T/48T
J01526 人甲状旁腺激素(PTH)ELISA试剂盒 human Parathyroid hormone,PTH ELISA Kit 96T/48T
J01527 人甲肟前列腺素D2(PGD2-MOX)ELISA试剂盒 human Prostaglandin D2-methoxime,PGD2-MOX ELISA Kit 96T/48T
J01528 人高敏甲状腺素(u-T4)ELISA试剂盒 human Ultrasensitivity Thyroxine,u-T4 ELISA Kit 96T/48T
J01529 人高灵敏度促甲状腺激素(U-TSH)ELISA试剂盒 human ultrasensitive thyroid-stimulating hormone,U-TSH ELISA Kit 96T/48T
J01530 人叠氮胸苷(AZT)ELISA试剂盒 human Azidothymidine,AZT ELISA Kit 96T/48T
J01531 人真核翻译起始因子3a(eIF3a)ELISA试剂盒 Human Eukaryotic translation initiation factor 3a,eIF3a ELISA Kit 96T/48T
J01532 人磷酸化细胞外信号调节激酶(pERK)ELISA试剂盒 Human phospho-extracellular signal-regulated kinase,pERK ELISA Kit 96T/48T
J01533 人受磷蛋白(PLN)ELISA试剂盒 Human phospholamban,PLN ELISA Kit 96T/48T
J01534 人肿瘤坏死因子相关弱凋亡诱导因子(TWEAK)ELISA试剂盒 Human tumour necrosis factor related weak inducer of apoptosis,TWEAK ELISA Kit 96T/48T
J01535 人IPO-38蛋白(IPO38)ELISA试剂盒 Human IPO-38 ELISA Kit 96T/48T
J01536 人切除修复交叉互补基因1(ERCC1)ELISA试剂盒 human excision repair cross-complementation group 1,ERCC1 ELISA Kit 96T/48T
J01537 人磷酸化核因子κB抑制蛋白α(pIKBα)ELISA试剂盒 human phospho-inhibitory subunit of NF-κBα,pIKBα ELISA Kit 96T/48T
J01538 人桩蛋白(Pax)ELISA试剂盒 Human paxillin,Pax ELISA Kit 96T/48T
J01539 人小乳腺表皮粘蛋白(SBEM)ELISA试剂盒 Human small breast epithelial mucin,SBEM ELISA Kit 96T/48T
J01540 人类似60S核糖体蛋白L21(LOC382344)ELISA试剂盒 human Mus musculus similar to 60S ribosomal protein L12,LOC382344 ELISA Kit 96T/48T
J01541 人类粘蛋白2(ORM2)ELISA试剂盒 human orosomucoid 2,ORM2 ELISA Kit 96T/48T
J01542 人MAX二聚化蛋白1(mxd1)ELISA试剂盒 human MAX dimerization protein 1,mxd1 ELISA Kit 96T/48T
J01543 人水闸蛋白14(CLDN14)ELISA试剂盒 human claudin 14,CLDN14 ELISA Kit 96T/48T
J01544 人可溶性半乳糖苷结合凝集素3(Lgals3)ELISA试剂盒 human lectin-galactose binding-soluble 3,Lgals3 ELISA Kit 96T/48T
J01545 人主要穹窿蛋白(MVP)ELISA试剂盒 human major vault protein,MVP ELISA Kit 96T/48T
J01546 人泛素蛋白D(UBD)ELISA试剂盒 human ubiquitin D,UBD ELISA Kit 96T/48T
J01547 人toll样受体2(TLR2)ELISA试剂盒 human toll-like receptor 2,TLR2 ELISA Kit 96T/48T
J01548 人青少年2型血色素沉着症/幼年型血色病相关蛋白2(HFE2)ELISA试剂盒 human hemochromatosis type 2/uvenile-uman homolog,HFE2 LISA Kit 96T/48T
J01549 人卷曲蛋白8(FZD8)ELISA试剂盒 human frizzled homolog 8,FZD8 ELISA Kit 96T/48T
J01550 人蜗牛同源物2(SNAI2)ELISA试剂盒 human snail homolog 2,SNAI2 ELISA Kit 96T/48T
J01551 人高尔基蛋白73(GP-73)ELISA试剂盒 Human golgi protein 73,GP-73 ELISA Kit 96T/48T
J01552 人TU3A蛋白(TU3A)ELISA试剂盒 Human TU3A Protein ELISA Kit 96T/48T
J01553 人电子转移黄素蛋白β肽(ETFB)ELISA试剂盒 Human electron-transfer-flavoprotein beta polypeptide,ETFB ELISA Kit 96T/48T
J01554 人皮肤蛋白(DPT)ELISA试剂盒 Human dermato-pontin,DPT ELISA Kit 96T/48T
J01555 人可溶性蛋白185(sp185/HER-2)ELISA试剂盒 Human soluble protein 185,sp185/HER-2 ELISA Kit 96T/48T
J01556 人降解加速因子(DAF)ELISA试剂盒 Human decay-accelerating factor,DAF ELISA Kit 96T/48T
J01557 人T细胞活化连接蛋白(LAT)ELISA试剂盒 Human Linker for activation of T cell,LAT ELISA Kit 96T/48T
J01558 人SH2携带蛋白(SHC/SLP-76)ELISA试剂盒 Human SH2-containing protein,SHC/SLP-76 ELISA Kit 96T/48T
J01559 人B细胞连接蛋白(BLNK)ELISA试剂盒 Human B-Cell Linker Protein,BLNK ELISA Kit 96T/48T
J01560 人尿素酶相关蛋白C(UreC)ELISA试剂盒 Human urease related protein C,UreC ELISA Kit 96T/48T
J01561 人衔接蛋白酶活化因子1(APAF1)ELISA试剂盒 Human adaptor molecule apoptotic peptidase activating factor 1,APAF1 ELISA Kit 96T/48T
J01562 人锚蛋白B(Ank-B)ELISA试剂盒 Human ankyrin B,Ank-B ELISA Kit 96T/48T
J01563 人潜伏膜蛋白1(LMP-1)ELISA试剂盒 Human latent membrane protein-1,LMP-1 ELISA Kit 96T/48T
J01564 人重组激活基因2(RAG-2)ELISA试剂盒 吞噬细胞运动蛋白2抗体Human recombination activating gene 2,RAG-2 ELISA Kit 96T/48T
J01565 人重组激活基因1(RAG-1)ELISA试剂盒 Human recombination activating gene 1,RAG-1 ELISA Kit 96T/48T
J01566 人NOD样受体(NLR)ELISA试剂盒 Human NOD-like receptor9,NLR ELISA Kit 96T/48T
J01567 人视黄酸诱导基因/RIG-1样受体(RLR)ELISA试剂盒 Human retinoic acid inducible gene/RIG-like receptor,RLR-9 ELISA Kit 96T/48T
J01568 人清道夫受体B(SRB/CD36)ELISA试剂盒 Human scavenger receptor B,SRB ELISA Kit 96T/48T
J01569 人杀菌肽B(CecB)ELISA试剂盒 Human cecropin B,CecB ELISA Kit 96T/48T
J01570 人抗菌肽(Att)ELISA试剂盒 Human Attacin,Att ELISA Kit 96T/48T
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