erbB3结合蛋白1抗体|0.2ml/200μg|-上海纪宁实业有限公司

产品详情

在免疫化学技术中影响erbB3结合蛋白1抗体效率的因素主要有5个方面：①抗体对抗原的亲合性；②抗体对抗原的特异性；③抗原表位结构在该技术中是如何被改变的；④抗体与抗原结合的易接近性；⑤二级试剂的质量和类型

英文名称 Anti-EBP1

中文名称 erbB3结合蛋白1抗体

别名 AA672939; Cell cycle protein p38 2G4 homolog; Cell cycle protein p38-2G4 homolog; ErbB-3 binding protein 1; ErbB3 binding protein 1; ErbB3-binding protein 1; ErbB3-binding protein Ebp1; hG4 1; hG4-1; IRES-specific cellular trans-acting factor 45 kDa; MGC81621; MGC94070; Mpp1; p38 2G4; PA2G4; PA2G4_HUMAN; Plfap; Proliferation associated 2G4; Proliferation associated 2G4, 38-KD; Proliferation-associated 2G4, 38kDa; Proliferation-associated 2G4, a; Proliferation-associated protein 1; Proliferation-associated protein 2G4; Protein p38-2G4; si:dz150i12.2; wu:fb19b11; wu:ft56d05; zgc:86732.

erbB3结合蛋白1抗体浓度 1mg/1ml

规格 0.2ml/200μg

抗体来源 Rabbit

克隆类型 polyclonal

交叉反应 Human, Mouse, Rat, Chicken, Pig, Cow, Rabbit, Zebrafish, Sheep

产品类型一抗

研究领域细胞生物转录调节因子表观遗传学

蛋白分子量 predicted molecular weight: 44kDa

性状 Lyophilized or Liquid

免疫原 KLH conjugated synthetic erbB3结合蛋白1抗体peptide derived from human EBP1

亚型 IgG

纯化方法 affinity purified by Protein A

储存液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500

（石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

产品介绍 EBP1 is a member of the peptidase M24C family and functions as an RNA-binding protein involved in cellular proliferation and differentiation processes. It is expressed in a variety of cell lines, including a wide range of tumor cell lines, and localizes to the cytoplasm. Upon treatment with Neuregulin-1 (heregulin), EBP1 translocates to the nucleus. EBP1 is a component of pre-ribosomal ribonucleoprotein complexes, participating in ribosome assembly and regulating the later steps of rRNA processing. In addition, EBP1 interacts with ErbB-3 and may function as a modulator of the ErbB-3-mediated signal transduction pathway by regulating the effects of Neuregulin-1 (heregulin). EBP1 also associates with histone deacetylases (HDACs), functioning as a transcriptional co-repressor of cell cycle regulatory genes.

Function : May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly. Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site).

Subunit : Interacts with the cytoplasmic domain of non-phosphorylated ERBB3; the interaction requires PKC activity. Interacts with AR. Treatment with HRG leads to dissociation from ERBB3 and increases association with AR. Interacts with NCL/nucleolin. Component of a ribonucleoprotein complex containing at least PA2G4, NCL, TOP1, PABPC2, RPLP0, acetylated histone H1 (HIST1H1A or H1F1), histone H1 2/4, RPL4, RPL8, RPL15, RPL18, RPL18A, RPL21, RPL11, RPL12, RPL28, RPL27, RPLP2 and RPL24. Interacts with HDAC2. Interacts with RB1; the interaction is enhanced upon PA2G4 dephosphorylation.

Subcellular Location : Cytoplasm. Nucleus > nucleolus. Tranlocates to the nucleus upon treatment with HRG.

Tissue Specificity : Expressed in several cell lines tested, including primary and transformed cell lines.

Post-translational modifications : Phosphorylated on serine and threonine residues. Phosphorylation is enhanced by HRG treatment. Basal phosphorylation is PKC-dependent and HRG-induced phosphorylation is predominantly PKC-independent.

Similarity : Belongs to the peptidase M24 family.

Database links : UniProtKB/Swiss-Prot: Q9UQ80.3

半个多世纪以来，抗体一直作为常用的研究工具，因此对其使用和储存已有丰富的经验。这些经验让人们知道如何对抗体进行操作，由于抗体的稳定性好，使用并不困难。抗体较其他蛋白不易变性，易于存放、纯化和标记。蛋白G和蛋白A等抗体结合蛋白的发现使得这项工作更具可行性。

选择合适的抗体对免疫化学技术的成功极为重要。没有任何一种来源的抗体能够满足本书所述的各种方法的要求。为了研究某一重要的抗原，应选用具有不同特性的多种抗体。在没有一套良好特性的抗体可用于研究机体中每一种蛋白之前，选择及制备适合各种技术要求的抗体非常必要。

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J01824 小鼠P选择素(P-Selectin/CD62P)ELISA试剂盒 Mouse P-Selectin ELISA Kit 96T/48T

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J01829 小鼠转化生长因子β1(TGF-β1)ELISA试剂盒 Mouse Transforming Growth factor β1,TGF-β1 ELISA Kit 96T/48T

J01830 小鼠肿瘤坏死因子可溶性受体Ⅰ(TNFsR-Ⅰ)ELISA试剂盒 Mouse Tumor necrosis factor soluble receptor Ⅰ,TNFsR-Ⅰ ELISA Kit 96T/48T

J01831 小鼠肿瘤坏死因子可溶性受体Ⅱ(TNFsR-Ⅱ)ELISA试剂盒 Mouse Tumor necrosis factor soluble receptor Ⅱ,TNFsR-Ⅱ ELISA Kit 96T/48T

J01832 小鼠肿瘤坏死因子α(TNF-α)ELISA试剂盒 Mouse Tumor necrosis factor α,TNF-α ELISA Kit 96T/48T

J01833 小鼠肿瘤坏死因子β(TNF-β)ELISA试剂盒 Mouse Tumor necrosis factor β,TNF-β ELISA Kit 96T/48T

J01834 小鼠Ⅳ型胶原(Col Ⅳ)ELISA试剂盒 Mouse Collagen Type Ⅳ,Col Ⅳ ELISA Kit 96T/48T

J01835 小鼠己糖激酶(HK)ELISA试剂盒 Mouse Hexokinase,HK ELISA Kit 96T/48T

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J01838 小鼠CXC趋化因子配体16(CXCL16)ELISA试剂盒 Mouse CXC-chemokine ligand 16,CXCL16 ELISA Kit 96T/48T

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J01862 小鼠骨粘连蛋白(ON)ELISA试剂盒 Mouse osteonectin,ON ELISA Kit 96T/48T

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供货周期：	一周
品牌：
规格：	0.2ml/200μg
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