酪氨酸蛋白激酶受体B6抗体|0.2ml/200μg|-上海纪宁实业有限公司

产品详情

在免疫化学技术中影响酪氨酸蛋白激酶受体B6抗体效率的因素主要有5个方面：①抗体对抗原的亲合性；②抗体对抗原的特异性；③抗原表位结构在该技术中是如何被改变的；④抗体与抗原结合的易接近性；⑤二级试剂的质量和类型

英文名称 Anti-EphB6

中文名称酪氨酸蛋白激酶受体B6抗体

别名 EPH receptor B6; EphB6; EPHB6_HUMAN; Ephrin type B receptor 6 precursor; Ephrin type-B receptor 6; HEP; MGC129910; MGC129911; Tyrosine protein kinase defective receptor EPH 6; Tyrosine-protein kinase-defective receptor EPH-6.

酪氨酸蛋白激酶受体B6抗体浓度 1mg/1ml

规格 0.1ml/100μg 0.2ml/200μg

抗体来源 Rabbit

克隆类型 polyclonal

交叉反应 Human, Mouse, Rat, Dog, Pig, Horse

产品类型一抗

研究领域免疫学发育生物学神经生物学信号转导生长因子和激素激酶和磷酸酶细胞类型标志物

蛋白分子量 predicted molecular weight: 111kDa

性状 Lyophilized or Liquid

免疫原 KLH conjugated synthetic peptide derived from human EphB6

亚型 IgG

纯化方法 affinity purified by Protein A

储存液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 IF=1:100-500

（石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

产品介绍 Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The ephrin receptor encoded by this gene lacks the kinase activity of most receptor tyrosine kinases and binds to ephrin-B ligands. [provided by RefSeq, Jul 2008].

Function : Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2.

Subunit : Interacts with CBL and EPHB1. Interacts with FYN; this interaction takes place in a ligand-independent manner.

Subcellular Location : Membrane; Single-pass type I membrane protein. Isoform 3: Secreted.

Tissue Specificity : Expressed in brain. Expressed in non invasive breast carcinoma cell lines (at protein level). Strong expression in brain and pancreas, and weak expression in other tissues, such as heart, placenta, lung, liver, skeletal muscle and kidney. Expressed in breast non invasive tumors but not in metastatic lesions. Isoform 3 is expressed in cell lines of glioblastomas, anaplastic astrocytomas, gliosarcomas and astrocytomas. Isoform 3 is not detected in normal tissues.

Post-translational modifications : Ligand-binding increases phosphorylation on tyrosine residues. Phosphorylation on tyrosine residues is mediated by transphosphorylation by the catalytically active EPHB1 in a ligand-independent manner. Tyrosine phosphorylation of the receptor may act as a switch on the functional transition from cell adhesion/attraction to de-adhesion/repulsion.

Similarity : Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.

Contains 1 Eph LBD (Eph ligand-binding) domain.

Contains 2 fibronectin type-III domains.

Database links : UniProtKB/Swiss-Prot: O15197.4

生长因子和激素（ Growth Factor and Hormones）

有学者认为：EPHB6受体型酪氨酸蛋白激酶与多种肿瘤的发生和转移负相关，EPHB6作为一种重要的生物学标记，还有许多未知的蛋白功能。

目前研究发现Ezrin蛋白与维持细胞的形状、极性、生长运动以及信号转导方面发挥重要作用，该蛋白与肿瘤的侵袭、转移有关。

半个多世纪以来，抗体一直作为常用的研究工具，因此对其使用和储存已有丰富的经验。这些经验让人们知道如何对抗体进行操作，由于抗体的稳定性好，使用并不困难。抗体较其他蛋白不易变性，易于存放、纯化和标记。蛋白G和蛋白A等抗体结合蛋白的发现使得这项工作更具可行性。

选择合适的抗体对免疫化学技术的成功极为重要。没有任何一种来源的抗体能够满足本书所述的各种方法的要求。为了研究某一重要的抗原，应选用具有不同特性的多种抗体。在没有一套良好特性的抗体可用于研究机体中每一种蛋白之前，选择及制备适合各种技术要求的抗体非常必要。

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J06027 人5羟基吲哚乙酸(5-HIAA)ELISA Kit，48T/96T

J06028 人高密度脂蛋白(HDL)ELISA Kit，48T/96T

J06029 人N-乙酰基-丝氨酰-天门冬酰-赖氨酰-脯氨酸ELISA Kit，48T/96T

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J06036 人高密度脂蛋白胆固醇(HDL-C)ELISA Kit，48T/96T

J06037 人P钙黏蛋白/胎盘钙黏蛋白(P-cad)ELISA Kit，48T/96T

J06038 人白细胞分化抗原4(CD4)ELISA Kit，48T/96T

J06039 人α1抗胰糜蛋白酶(AACT)ELISA Kit，48T/96T

J06040 人γ肽(Pγ)ELISA Kit，48T/96T

J06041 人α2巨球蛋白(α2-MG)ELISA Kit，48T/96T

J06042 人α乳清蛋白(α-La)ELISA Kit，48T/96T

J06043 人β2糖蛋白(β2-GP)ELISA Kit，48T/96T

J06044 人淀粉样前体蛋白(βAPP)ELISA Kit，48T/96T

J06045 人β连环蛋白/联蛋白(β-Cat)ELISA Kit，48T/96T

J06046 牛β羟丁酸(βOHB)ELISA Kit，48T/96T

J06047 人β羟丁酸(β-OHB)ELISA Kit，48T/96T

J06048 大鼠β羟丁酸(βOHB)ELISA Kit，48T/96T

J06049 人β乳球蛋白(β-Lg)ELISA Kit，48T/96T

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J06053 人泛素激活酶(E1/UBAE)ELISA Kit，48T/96T

J06054 人血清白蛋白(HSA)ELISA Kit，48T/96T

J06055 人白色念珠菌(C.albicans)ELISA Kit，48T/96T

J06056 人白细胞共同抗原(LCA/CD45)ELISA Kit，48T/96T

J06057 人百日咳毒素(PT)ELISA Kit，48T/96T

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J06061 人苯丙酸诺龙/苯丙酸去甲睾酮(NP)ELISA Kit，48T/96T

J06062 人鼻咽癌(NPC)ELISA Kit，48T/96T

J06063 人吡啶酚(PYD)ELISA Kit，48T/96T

J06064 酪氨酸蛋白激酶受体B6抗体人γ谷氨酰半胱氨酸合成酶(γ-ECS)ELISA Kit，48T/96T

J06065 人表面活性蛋白D(SP-D)ELISA Kit，48T/96T

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J06068 人空泡毒素相关蛋白A(VacA)ELISA Kit，48T/96T

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供货周期：	一周
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规格：	0.2ml/200μg
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