英文名称 Anti-ESRRG/Estrogen Related Receptor gamma
中文名称 雌激素受体相关蛋白3抗体
别 名 ERR 3; ERR G2; ERR gamma 2; ERR gamma-2; ERR3; ERR3_HUMAN; ERRG 2; ERRG2; ESRRG; Estrogen receptor related protein 3; Estrogen receptor-related protein 3; Estrogen-related receptor gamma; NR3B3; Nuclear receptor subfamily 3 group B member 3.
雌激素受体相关蛋白3抗体浓 度 1mg/1ml
规 格 0.2ml/200μg
抗体来源 Rabbit
克隆类型 polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep
产品类型 一抗
研究领域 肿瘤 细胞生物 染色质和核信号 信号转导 转录调节因子
蛋白分子量 predicted molecular weight: 51kDa
性 状 Lyophilized or Liquid
免 疫 原 KLH conjugated synthetic peptide derived from human ESRRG/Estrogen Related Receptor gamma
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 This gene encodes a member of the estrogen receptor-related receptor (ESRR) family, which belongs to the nuclear hormone receptor superfamily. All members of the ESRR family share an almost identical DNA binding domain, which is composed of two C4-type zinc finger motifs. The ESRR members are orphan nuclear receptors; they bind to the estrogen response element and steroidogenic factor 1 response element, and activate genes controlled by both response elements in the absence of any ligands. The ESRR family is closely related to the estrogen receptor (ER) family. They share target genes, co-regulators and promoters, and by targeting the same set of genes, the ESRRs seem to interfere with the ER-mediated estrogen response in various ways. It has been reported that the family member encoded by this gene functions as a transcriptional activator of DNA cytosine-5-methyltransferases 1 (Dnmt1) expression by direct binding to its response elements in the DNMT1 promoters, modulates cell proliferation and estrogen signaling in breast cancer, and negatively regulates bone morphogenetic protein 2-induced osteoblast differentiation and bone formation. Multiple alternatively spliced transcript variants have been identified, which mainly differ at the 5' end and some of which encode protein isoforms differing in the N-terminal region.
Function : Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements
Subunit : Homodimer. Binds TLE1, PNRC1 and PNRC2. Binds GRIP1 (By similarity). Interacts with NRIP1, NCOA1 and NCOR2.
Subcellular Location : Nucleus
Tissue Specificity : Expressed in the heart, kidney, brain, lung, bone marrow, adrenal gland, trachea, spinal cord and thyroid gland.
Post-translational modifications : Sumoylation on Lys-40 is enhanced by phosphorylation at Ser-45 and represses transcriptional activity.
Phosphorylation on Ser-45 enhances sumoylation on Lys-40 thus repressing transcriptional activity.
Similarity : Belongs to the nuclear hormone receptor family. NR3 subfamily.
Contains 1 nuclear receptor DNA-binding domain.
半个多世纪以来，抗体一直作为常用的研究工具，因此对其使用和储存已有丰富的经验。这些经验让人们知道如何对抗体进行操作，由于抗体的稳定性好，使用并不困难。抗体较其他蛋白不易变性，易于存放、纯化和标记。蛋白G和蛋白A等抗体结合蛋白的发现使得这项工作更具可行性。
选择合适的抗体对免疫化学技术的成功极为重要。没有任何一种来源的抗体能够满足本书所述的各种方法的要求。为了研究某一重要的抗原，应选用具有不同特性的多种抗体。在没有一套良好特性的抗体可用于研究机体中每一种蛋白之前，选择及制备适合各种技术要求的抗体非常必要。
J10945 载脂蛋白B100(APOB100)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Apolipoprotein B100 (APOB100) 48T/96T Rattus norvegicus (Rat)
J10946 载脂蛋白A2(APOA2)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Apolipoprotein A2 (APOA2) 48T/96T Homo sapiens (Human)
J10947 载脂蛋白A2(APOA2)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Apolipoprotein A2 (APOA2) 48T/96T Mus musculus (Mouse)
J10948 载脂蛋白A2(APOA2)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Apolipoprotein A2 (APOA2) 48T/96T Rattus norvegicus (Rat)
J10949 P选择素(SELP)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Selectin, Platelet (SELP) 48T/96T Sus scrofa; Porcine (Pig)
J10950 层粘连蛋白α1(LAMα1)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Laminin Alpha 1 (LAMa1) 48T/96T Homo sapiens (Human)
J10951 层粘连蛋白α1(LAMα1)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Laminin Alpha 1 (LAMa1) 48T/96T Mus musculus (Mouse)
J10952 层粘连蛋白α1(LAMα1)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Laminin Alpha 1 (LAMa1) 48T/96T Rattus norvegicus (Rat)
J10953 磷脂酶A2激活蛋白(PLAA)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Phospholipase A2 Activating Protein (PLAA) 48T/96T Homo sapiens (Human)
J10954 碱性鞘磷脂磷酸二酯酶(Alk-Smase)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Alkaline Sphingomyelinase (Alk-Smase) 48T/96T Rattus norvegicus (Rat)
J10955 碱性鞘磷脂磷酸二酯酶(Alk-Smase)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Alkaline Sphingomyelinase (Alk-Smase) 48T/96T Mus musculus (Mouse)
J10956 碱性鞘磷脂磷酸二酯酶(Alk-Smase)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Alkaline Sphingomyelinase (Alk-Smase) 48T/96T Homo sapiens (Human)
J10957 胆囊收缩素(CCK)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Cholecystokinin (CCK) 48T/96T Rattus norvegicus (Rat)
J10958 胆囊收缩素(CCK)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Cholecystokinin (CCK) 48T/96T Mus musculus (Mouse)
J10959 胆囊收缩素(CCK)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Cholecystokinin (CCK) 48T/96T Homo sapiens (Human)
J10960 胰高血糖素样肽1(GLP1)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Glucagon Like Peptide 1 (GLP1) 48T/96T Rattus norvegicus (Rat)
J10961 胰高血糖素样肽1(GLP1)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Glucagon Like Peptide 1 (GLP1) 48T/96T Mus musculus (Mouse)
J10962 胰高血糖素样肽1(GLP1)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Glucagon Like Peptide 1 (GLP1) 48T/96T Homo sapiens (Human)
J10963 骨成型蛋白7(BMP7)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Bone Morphogenetic Protein 7 (BMP7) 48T/96T Homo sapiens (Human)
J10964 骨成型蛋白7(BMP7)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Bone Morphogenetic Protein 7 (BMP7) 48T/96T Rattus norvegicus (Rat)
J10965 骨成型蛋白7(BMP7)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Bone Morphogenetic Protein 7 (BMP7) 48T/96T Mus musculus (Mouse)
J10966 淋巴细胞功能关联抗原3(LFA3)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Lymphocyte Function Associated Antigen 3 (LFA3) 48T/96T Homo sapiens (Human)
J10967 淋巴细胞功能关联抗原2(LFA2)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Lymphocyte Function Associated Antigen 2 (LFA2) 48T/96T Rattus norvegicus (Rat)
J10968 淋巴细胞功能关联抗原2(LFA2)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Lymphocyte Function Associated Antigen 2 (LFA2) 48T/96T Mus musculus (Mouse)
J10969 血红蛋白μ(HBμ)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Hemoglobin Mu (HBm) 48T/96T Homo sapiens (Human)
J10970 胰岛素受体(ISR)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Insulin Receptor (ISR) 48T/96T Homo sapiens (Human)
J10971 胰岛素受体(ISR)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Insulin Receptor (ISR) 48T/96T Mus musculus (Mouse)
J10972 胰岛素受体(ISR)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Insulin Receptor (ISR) 48T/96T Rattus norvegicus (Rat)
J10973 促肾上皮质激素释放激素(CRH)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Corticotropin Releasing Hormone (CRH) 48T/96T Mus musculus (Mouse)
J10974 促甲状腺素释放激素(TRH)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Thyrotropin Releasing Hormone (TRH) 48T/96T Homo sapiens (Human)
J10975 促甲状腺素释放激素(TRH)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Thyrotropin Releasing Hormone (TRH) 48T/96T Mus musculus (Mouse)
J10976 诱导型一氧化氮合酶(NOS2)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Nitric Oxide Synthase 2, Inducible (NOS2) 48T/96T Homo sapiens (Human)
J10977 抑制素βA(INHβA)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Inhibin Beta A (INHbA) 48T/96T Homo sapiens (Human)
J10978 抑制素βA(INHβA)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Inhibin Beta A (INHbA) 48T/96T Rattus norvegicus (Rat)
J10979 抑制素βA(INHβA)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Inhibin Beta A (INHbA) 48T/96T Mus musculus (Mouse)
J10980 促性腺激素释放激素(GnRH)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Gonadotropin Releasing Hormone (GnRH) 48T/96T Mus musculus (Mouse)
J10981 促微管蛋白聚合蛋白(TPPP)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Tubulin Polymerization Promoting Protein (TPPP) 48T/96T Homo sapiens (Human)
J10982 促微管蛋白聚合蛋白(TPPP)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Tubulin Polymerization Promoting Protein (TPPP) 48T/96T
J10983 促微管蛋白聚合蛋白(TPPP)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Tubulin Polymerization Promoting Protein (TPPP) 48T/96T Mus musculus (Mouse)
J10984 核因子κB受体激活因子配基(RANκL)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) 48T/96T Homo sapiens (Human)
J10985 核因子κB受体激活因子配基(RANκL)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) 48T/96T Rattus norvegicus (Rat)
J10986 核因子κB受体激活因子配基(RANκL)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) 48T/96T Mus musculus (Mouse)
J10987 凝溶胶蛋白(GS)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Gelsolin (GS) 48T/96T Homo sapiens (Human)
J10988 凝溶胶蛋白(GS)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Gelsolin (GS) 48T/96T Rattus norvegicus (Rat)
J10989 凝溶胶蛋白(GS)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Gelsolin (GS) 48T/96T Mus musculus (Mouse)
J10990 血管生成素样蛋白1(ANGPTL1)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Angiopoietin Like Protein 1 (ANGPTL1) 48T/96T Homo sapiens (Human)
J10991 血管生成素样蛋白1(ANGPTL1)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Angiopoietin Like Protein 1 (ANGPTL1) 48T/96T Rattus norvegicus (Rat)
J10992 血管生成素样蛋白1(ANGPTL1)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Angiopoietin Like Protein 1 (ANGPTL1) 48T/96T Mus musculus (Mouse)
J10993 上皮中性粒细胞激活肽78(ENA78)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Epithelial Neutrophil Activating Peptide 78 (ENA78) 48T/96T Homo sapiens (Human)
J10994 上皮中性粒细胞激活肽78(ENA78)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Epithelial Neutrophil Activating Peptide 78 (ENA78) 48T/96T Rattus norvegicus (Rat)
J10995 上皮中性粒细胞激活肽78(ENA78)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Epithelial Neutrophil Activating Peptide 78 (ENA78) 48T/96T Mus musculus (Mouse)
J10996 10kDa干扰素γ诱导蛋白(IP10)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Interferon Gamma Induced Protein 10kDa (IP10) 48T/96T Homo sapiens (Human)
J10997 10kDa干扰素γ诱导蛋白(IP10)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Interferon Gamma Induced Protein 10kDa (IP10) 48T/96T Rattus norvegicus (Rat)
J10998 10kDa干扰素γ诱导蛋白(IP10)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Interferon Gamma Induced Protein 10kDa (IP10) 48T/96T Mus musculus (Mouse)
J10999 GATA结合蛋白4(GATA4)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for GATA Binding Protein 4 (GATA4) 48T/96T Homo sapiens (Human)
J11000 GATA结合蛋白4(GATA4)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for GATA Binding Protein 4 (GATA4) 48T/96T Rattus norvegicus (Rat)
J11001 GATA结合蛋白4(GATA4)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for GATA Binding Protein 4 (GATA4) 48T/96T Mus musculus (Mouse)
J11002 结蛋白(Des)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Desmin (Des) 48T/96T Homo sapiens (Human)
J11003 结蛋白(Des)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Desmin (Des) 48T/96T Rattus norvegicus (Rat)
J11004 结蛋白(Des)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Desmin (Des) 48T/96T Mus musculus (Mouse)
J11005 肌球蛋白ⅠA(MYO1A)雌激素受体相关蛋白3抗体检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Myosin IA (MYO1A) 48T/96T Homo sapiens (Human)
J11006 肌球蛋白ⅠA(MYO1A)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Myosin IA (MYO1A) 48T/96T Rattus norvegicus (Rat)
J11007 肌球蛋白ⅠA(MYO1A)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Myosin IA (MYO1A) 48T/96T Mus musculus (Mouse)
J11008 辅肌动蛋白α2(ACTN2)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Actinin Alpha 2 (ACTN2) 48T/96T Homo sapiens (Human)
J11009 垂体腺苷酸环化酶激活肽(ADCYAP1)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Adenylate Cyclase Activating Polypeptide 1, Pituitary (ADCYAP1) 48T/96T Mus musculus (Mouse)
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