英文名称 Anti-Alpha-ENaC
中文名称 钠通道蛋白α ENaC
别 名 Alpha ENaC 2; Alpha ENaC; Alpha NaCH; Alpha-ENaC; Alpha-NaCH; Amiloride sensitive epithelial sodium channel alpha subunit; Amiloride sensitive sodium channel subunit alpha; Amiloride-sensitive sodium channel subunit alpha; ENaCa; ENaCalpha; Epithelial Na(+) channel subunit alpha; Epithelial Na+ channel subunit alpha; FLJ21883; Nonvoltage gated sodium channel 1 subunit alpha; Nonvoltage-gated sodium channel 1 subunit alpha; SCNEA; SCNN 1; SCNN1; SCNN1A; SCNNA_HUMAN; Sodium channel nonvoltage gated 1 alpha.
钠通道蛋白α ENaC浓 度 1mg/1ml
规 格 0.2ml/200μg
抗体来源 Rabbit
克隆类型 polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep
产品类型 一抗
研究领域 神经生物学 信号转导 细胞膜受体
蛋白分子量 predicted molecular weight: 76kDa
性 状 Lyophilized or Liquid
免 疫 原 KLH conjugated synthetic peptide derived from human Alpha-ENaC
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.
Function : Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.
Subunit : Probable heterotrimer containing one alpha, one beta and one gamma subunit. A delta subunit can replace the alpha subunit. Interacts with the WW domains of NEDD4, NEDD4L, WWP1 and WWP2. Interacts with the full length immature form of PCSK9 (pro-PCSK9).
Subcellular Location : Apical cell membrane; Multi-pass membrane protein.
Tissue Specificity : Highly expressed in kidney and lung. Detected at intermediate levels in pancreas and liver, and at low levels in heart and placenta. Isoform 1 and isoform 2 predominate in all tissues. Expression of isoform 3, isoform 4 and isoform 5 is very low or not detectable, except in lung and heart.
Post-translational modifications : Ubiquitinated; this targets individual subunits for endocytosis and proteasome-mediated degradation (By similarity).
ENaC cleavage by furin, and subsequently by prostasin (PRSS8), leads to a stepwise increase in the open probability of the channel as a result of release of the alpha and gamma subunit inhibitory tracts, respectively.
DISEASE : Pseudohypoaldosteronism 1, autosomal recessive (PHA1B) [MIM:264350]: A rare salt wasting disease resulting from target organ unresponsiveness to mineralocorticoids. PHA1B is a severe form involving multiple organ systems, and characterized by an often fulminant presentation in the neonatal period with dehydration, hyponatremia, hyperkalemia, metabolic acidosis, failure to thrive and weight loss. Note=The disease is caused by mutations affecting the gene represented in this entry. The degree of channel function impairment differentially affects the renin-aldosterone system and urinary Na/K ratios, resulting in distinct genotype-phenotype relationships in PHA1 patients. Loss-of-function mutations are associated with a severe clinical course and age-dependent hyperactivation of the renin-aldosterone system. This feature is not observed in patients with missense mutations that reduce but do not eliminate channel function. Markedly reduced channel activity results in impaired linear growth and delayed puberty (PubMed:18634878).
Bronchiectasis with or without elevated sweat chloride 2 (BESC2) [MIM:613021]: A debilitating respiratory disease characterized by chronic, abnormal dilatation of the bronchi and other cystic fibrosis-like symptoms in the absence of known causes of bronchiectasis (cystic fibrosis, autoimmune diseases, ciliary dyskinesia, common variable immunodeficiency, foreign body obstruction). Clinical features include sub-normal lung function, sinopulmonary infections, chronic productive cough, excessive sputum production, and elevated sweat chloride in some cases. Note=The disease is caused by mutations affecting the gene represented in this entry.
Similarity : Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1A subfamily.
Database links : UniProtKB/Swiss-Prot: P37088.1
αENaC
半个多世纪以来，抗体一直作为常用的研究工具，因此对其使用和储存已有丰富的经验。这些经验让人们知道如何对抗体进行操作，由于抗体的稳定性好，使用并不困难。抗体较其他蛋白不易变性，易于存放、纯化和标记。蛋白G和蛋白A等抗体结合蛋白的发现使得这项工作更具可行性。
选择合适的抗体对免疫化学技术的成功极为重要。没有任何一种来源的抗体能够满足本书所述的各种方法的要求。为了研究某一重要的抗原，应选用具有不同特性的多种抗体。在没有一套良好特性的抗体可用于研究机体中每一种蛋白之前，选择及制备适合各种技术要求的抗体非常必要。
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J11206 红藻氨酸离子能谷氨酸受体2(GRIK2)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Glutamate Receptor, Ionotropic, Kainate 2 (GRIK2) 48T/96T Homo sapiens (Human)
J11207 红藻氨酸离子能谷氨酸受体2(GRIK2)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Glutamate Receptor, Ionotropic, Kainate 2 (GRIK2) 48T/96T Rattus norvegicus (Rat)
J11208 叉头框蛋白P3(FOXP3)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Forkhead Box Protein P3 (FOXP3) 48T/96T Mus musculus (Mouse)
J11209 90kDa热休克蛋白β1(HSP90β1)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Heat Shock Protein 90kDa Beta 1 (HSP90b1) 48T/96T Bos taurus; Bovine (Cattle)
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J11211 血管紧张素转化酶(ACE)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Angiotensin I Converting Enzyme (ACE) 48T/96T Sus scrofa; Porcine (Pig)
J11212 血管内皮生长因子受体2(VEGFR2)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) 48T/96T Rattus norvegicus (Rat)
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J11214 肝脂酶(LIPC)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Lipase, Hepatic (LIPC) 48T/96T Sus scrofa; Porcine (Pig)
J11215 胆囊收缩素八肽(CCK8)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Cholecystokinin 8, Octapeptide (CCK8) 48T/96T Rattus norvegicus (Rat)
J11216 胆囊收缩素八肽(CCK8)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Cholecystokinin 8, Octapeptide (CCK8) 48T/96T Mus musculus (Mouse)
J11217 反三碘甲状腺原氨酸(rT3)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Reverse Triiodothyronine (rT3) 48T/96T General
J11218 粘蛋白5AC(MUC5AC)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Mucin 5 Subtype AC (MUC5AC) 48T/96T Rattus norvegicus (Rat)
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J11220 葡萄糖转运蛋白4(GLUT4)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Glucose Transporter 4 (GLUT4) 48T/96T Homo sapiens (Human)
J11221 蛋白激酶Cζ(PKCζ)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Protein Kinase C Zeta (PKCz) 48T/96T Mus musculus (Mouse)
J11222 蛋白酪氨酸磷酸酶受体O(PTPRO)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Protein Tyrosine Phosphatase Receptor Type O (PTPRO) 48T/96T Mus musculus (Mouse)
J11223 线粒体乙醛脱氢酶(ALDM)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Aldehyde Dehydrogenase, Mitochondrial (ALDM) 48T/96T Homo sapiens (Human)
J11224 酸性磷酸酶1(ACP1)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Acid Phosphatase 1 (ACP1) 48T/96T Rattus norvegicus (Rat)
J11225 酸性磷酸酶1(ACP1)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Acid Phosphatase 1 (ACP1) 48T/96T Mus musculus (Mouse)
J11226 角蛋白8(KRT8)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Keratin 8 (KRT8) 48T/96T Homo sapiens (Human)
J11227 生长分化因子15(GDF15)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Growth Differentiation Factor 15 (GDF15) 48T/96T Homo sapiens (Human)
J11228 白介素8(IL8)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Interleukin 8 (IL8) 48T/96T Chicken (Gallus)
J11229 生长分化因子15(GDF15)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Growth Differentiation Factor 15 (GDF15) 48T/96T Rattus norvegicus (Rat)
J11230 生长分化因子15(GDF15)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Growth Differentiation Factor 15 (GDF15) 48T/96T Mus musculus (Mouse)
J11231 金属硫蛋白3(MT3)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Metallothionein 3 (MT3) 48T/96T Rattus norvegicus (Rat)
J11232 纤维蛋白原降解产物(FDP)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Fibrinogen Degradation Product (FDP) 48T/96T Oryctolagus cuniculus (Rabbit)
J11233 骨钙素(OC)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Osteocalcin (OC) 48T/96T Oryctolagus cuniculus (Rabbit)
J11234 补体成分5(C5)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Complement Component 5 (C5) 48T/96T Rattus norvegicus (Rat)
J11235 S100钙结合蛋白A7(S100A7)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for S100 Calcium Binding Protein A7 (S100A7) 48T/96T Mus musculus (Mouse)
J11236 转铁蛋白(TRF)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Transferrin (TRF) 48T/96T Bos taurus; Bovine (Cattle)
J11237 凝血因子ⅩⅢB肽(F13B)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Coagulation Factor XIII B Polypeptide (F13B) 48T/96T Mus musculus (Mouse)
J11238 脑钠素(BNP)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Brain Natriuretic Peptide (BNP) 48T/96T Canis familiaris; Canine (Dog)
J11239 三磷酸肌醇(IP3)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Inositol Triphosphate (IP3) 48T/96T General
J11240 肿瘤坏死因子β(TNFβ)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Tumor Necrosis Factor Beta (TNFb) 48T/96T Chicken (Gallus)
J11241 免疫球蛋白A(IgA)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Immunoglobulin A (IgA) 48T/96T Sus scrofa; Porcine (Pig)
J11242 磷脂酰肌醇特异性磷酯酶Cβ1(PLCβ1)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Phospholipase C Beta 1, Phosphoinositide Specific (PLCb1) 48T/96T Mus musculus (Mouse)
J11243 二酰基甘油(DAG)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Diacylglycerol (DAG) 48T/96T General
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J11246 葡萄糖转运蛋白2(GLUT2)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Glucose Transporter 2 (GLUT2) 48T/96T Homo sapiens (Human)
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J11249 法尼酯X受体(FXR)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Farnesoid X Receptor (FXR) 48T/96T Homo sapiens (Human)
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J11252 蛋白激酶Cδ(PKCδ)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Protein Kinase C Delta (PKCd) 48T/96T Mus musculus (Mouse)
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J11254 葡萄糖转运蛋白4(GLUT4)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Glucose Transporter 4 (GLUT4) 48T/96T Mus musculus (Mouse)
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J11258 S100钙结合蛋白P(S100P)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for S100 Calcium Binding Protein P (S100P) 48T/96T Homo sapiens (Human)
J11259 磷脂酰肌醇特异性磷酯酶Cβ1(PLCβ1)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Phospholipase C Beta 1, Phosphoinositide Specific (PLCb1) 48T/96T Rattus norvegicus (Rat)
J11260 肌球蛋白轻链激酶(MYLK)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Myosin Light Chain Kinase (MYLK) 48T/96T Rattus norvegicus (Rat)
J11261 类胰蛋白酶(TPS)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Tryptase (TPS) 48T/96T Canis familiaris; Canine (Dog)
J11262 类胰蛋白酶(TPS)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Tryptase (TPS) 48T/96T Rattus norvegicus (Rat)
J11263 CCAAT增强子结合蛋白β(CEBPβ)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for CCAAT/Enhancer Binding Protein Beta (CEBPb) 48T/96T Rattus norvegicus (Rat)
J11264 肝素结合性表皮生长因子(HBEGF)钠通道蛋白α ENaC检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) 48T/96T Rattus norvegicus (Rat)
J11265 维生素D结合蛋白(DBP)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Vitamin D Binding Protein (DBP) 48T/96T Rattus norvegicus (Rat)
J11266 表皮生长因子受体2(EGFR2)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Epidermal Growth Factor Receptor 2 (EGFR2) 48T/96T Rattus norvegicus (Rat)
J11267 肌球蛋白重链2(MYH2)检测试剂盒(酶联免疫吸附试验法) ELISA Kit for Myosin Heavy Chain 2, Skeletal Muscle, Adult (MYH2) 48T/96T Rattus norvegicus (Rat)
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