褪黑素受体1B抗体保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin.
Function : High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.
Subcellular Location : Cell membrane; Multi-pass membrane protein.
Tissue Specificity : Expressed in retina and less in brain and hippocampus.
Similarity : Belongs to the G-protein coupled receptor 1 family.
Database links : UniProtKB/Swiss-Prot: P49286.1
Entrez Gene: 4544 Human
Omim: 600804 Human
SwissProt: P49286 Human
Unigene: 569039 Human
有学者认为：MTNR1B是组成控制褪黑激素信号通路的一部分。
褪黑激素调解人体的昼夜节律，是通过白天和黑夜来控制睡眠和饮食的内部时钟。MTNR1B的进一步研究为高血糖和糖尿病与昼夜节律遭到破坏有直接关系这一观点提供了证据。
英文名称 Anti-MTNR1B
中文名称 褪黑素受体1B抗体
别 名 MT2;melatonin receptor type 1B;melatonin receptor;MEL1B;MTNR1B;MEL-1B-R;Mtnr1b;MGC129286;MGC129287; MTNR-1B; Melatonin receptor 1B; MTR1B_HUMAN.
浓 度 1mg/1ml
规 格 0.1ml/100μg 0.2ml/200μg
抗体来源 Rabbit
克隆类型 polyclonal
交叉反应 Human, Mouse, Rat, Dog
产品类型 一抗
研究领域 细胞生物 免疫学 神经生物学 生长因子和激素 细胞膜受体
蛋白分子量 predicted molecular weight: 40kDa
褪黑素受体1B抗体性 状 Lyophilized or Liquid
免 疫 原 KLH conjugated synthetic peptide derived from human MTNR1B C-terminus
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
工商信息
信息已认证
