英文名称 Anti-APBA2
中文名称 β淀粉样前体蛋白结合蛋白2抗体（X11β）
别 名 Adapter protein X11beta; Amyloid beta A4 precursor protein-binding family A member 2; APBA2; APBA2_HUMAN; D15S1518E; HsT16821; LIN 10; Mint 2; Mint-2; Neuron-specific X11L protein; Neuronal Munc18-1-interacting protein 2; Phosphotyrosine binding/interacting domain (PTB) bearing protein; X11 beta; X11l.
浓 度 1mg/1ml
规 格 0.2ml/200μg
抗体来源 Rabbit
克隆类型 polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Horse, Rabbit, Sheep
产品类型 一抗
研究领域 细胞生物 神经生物学 Alzheimer's
蛋白分子量 predicted molecular weight: 82kDa
性 状 Lyophilized or Liquid
β淀粉样前体蛋白结合蛋白2抗体（X11β）免 疫 原 KLH conjugated synthetic peptide derived from human APBA2 (351-450aa)
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
产品应用 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
β淀粉样前体蛋白结合蛋白2抗体（X11β）产品介绍 The Beta-Amyloid precursor protein (Beta-APP) is a major constituent of the amyloid deposits in patients with Alzheimer’s disease. The Beta-Amyloid precursor is known to interact with several proteins, including X11 and the G heterotrimetric protein APP-BP1. The neuronal, transmembrane protein X11 is known to bind to the ∫-Amyloid precursor protein via a phosphotyrosine binding (PTB) domain, reducing the secretion of cellular Beta-APP and slowing Beta-APP processing pathways. X11 binds specifically to the YENPTY motif, which is involved in the internalization of Beta-APP. Multiple splice varitents of X11 have been identified, including X11 Alpha (also designated Mint 1), X11 Beta (Mint 2) and X11 Gamma(Mint 3).
Function : Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the beta-amyloid precursor protein (APP) and hence formation of beta-APP.
Subunit : Part of a multimeric complex containing STXBP1 and syntaxin-1. Binds to the cytoplasmic domain of amyloid protein beta, and to the nuclear factor NF-kappa-B/p65 via its PDZ domain. Interacts with the N-terminal domain of APBA2BP.
Tissue Specificity : Brain.
Similarity : Contains 2 PDZ (DHR) domains.
Contains 1 PID domain.
Database links : UniProtKB/Swiss-Prot: Q99767.3
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