乙酰化组蛋白H1b抗体

英文名称  Anti-Acetyl-Histone H1.4 (K53) 

中文名称  乙酰化组蛋白H1b抗体 

别    名  Histone H1.4(Ac-Lys53); Histone H1b (Ac-Lys53); Acetyl-Histone H1.4 (Lys53); HIST1H1E; H1F4; Histone H1.4; Histone H1b; H14_HUMAN; Histone H1s-4. 

浓    度  1mg/1ml 

规 格  0.1ml/100μg   

抗体来源  Rabbit  

克隆类型  polyclonal 

交叉反应  Human, Mouse, Rat, Dog, Pig, Cow, Horse   

产品类型  一抗  乙酰化抗体   

乙酰化组蛋白H1b抗体研究领域  肿瘤 发育生物学 信号转导 细胞凋亡 转录调节因子 表观遗传学  

蛋白分子量  predicted molecular weight: 24kDa 

性    状  Lyophilized or Liquid 

免 疫 原  KLH conjugated Synthesised acetylpeptide derived from human Histone H1b around the acetylation site of Lys53 

亚    型  IgG 

纯化方法  affinity purified by Protein A 

储 存 液  0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide 

产品应用   WB=1:100-500  ELISA=1:500-1000  IP=1:20-100  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500 

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

乙酰化组蛋白H1b抗体产品介绍 Histone H1b are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.

Function : Histones H1 are necessary for the condensation of nucleosome chains into higher order structures.

Subcellular Location : Nucleus. Chromosome.

Post-translational modifications : Acetylated at Lys-26. Deacetylated at Lys-26 by SIRT1.

Similarity : Belongs to the histone H1/H5 family.

Contains 1 H15 (linker histone H1/H5 globular) domain.

Database links : UniProtKB/Swiss-Prot: P10412.2 

转录调节因子（Transcriptin Regulators）