DAP凋亡诱导蛋白激酶2抗体

浓    度  1mg/1ml 

规 格  0.2ml/200μg          

抗体来源  Rabbit  

克隆类型  polyclonal 

交叉反应  Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep   

产品类型  一抗    

研究领域  肿瘤 免疫学 信号转导 细胞凋亡 转录调节因子 激酶和磷酸酶  

蛋白分子量  predicted molecular weight: 42kDakDa 

性    状  Lyophilized or Liquid 

免 疫 原  KLH conjugated synthetic peptide derived from human DRAK2 

亚    型  IgG 

纯化方法  affinity purified by Protein A 

储 存 液  0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide 

产品应用   WB=1:100-500  ELISA=1:500-1000  IP=1:20-100  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500 

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

DAP凋亡诱导蛋白激酶2抗体产品介绍 Apoptosis is mediated by death domain containing adapter molecules and a caspase family of proteases. Certain serine/threonine protein kinases, such as ASK1 and RIP, are mediators of apoptosis. Two novel serine/threonine kinases that induce apoptosis were recently identified and designated DRAK1 and DRAK2 (for DAP kinase related apoptosis inducing protein kinases). DRAKs contain an N terminal kinase domain and a C terminal regulation domain. Overexpression of DRAK2 induces apoptosis. DRAKs have high sequence homology to DAP and ZIP kinases, and they represent a novel family of serine/threonine kinases, which mediates apoptosis through their catalytic activities. DRAK2 is located in nucleus and the messenger RNA was ubiquitously expressed in human tissues.

Function : Acts as a positive regulator of apoptosis.

Subunit : Interacts with CHP1; the interaction induces CHP1 to translocate from the Golgi to the nucleus (By similarity). 

Subcellular Location : Nucleus. Cell membrane (By similarity). Endoplasmic reticulum-Golgi intermediate compartment (By similarity). Note=Colocalizes with STK17B at the plasma membrane (By similarity).

Tissue Specificity : Highly expressed in placenta, lung, pancreas. Lower levels in heart, brain, liver, skeletal muscle and kidney.

Post-translational modifications : Autophosphorylated.

Similarity : Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.

DAP kinase subfamily. Contains 1 protein kinase domain.

Database links : UniProtKB/Swiss-Prot: O94768