Notch信号通路Delta样配体4抗体

Notch信号通路Delta样配体4抗体英文名称  Anti-DLL4/Delta 4 

中文名称  Notch信号通路Delta样配体4抗体 

别    名  Delta 4; delta 4 precursor; Delta-4: Delta ligand 4; delta ligand 4 precursor; Delta like 4; Delta like 4 homolog; Delta like 4 protein; Delta like protein 4; Delta-like 4 (Drosophila); Delta-like protein 4; Delta4; DLL 4; DLL4; DLL4_HUMAN antibody Drosophila Delta homolog 4; hdelta2; Homeobox protein DLL-4; MGC126344; Notch ligand delta 2; Notch ligand DLL4; notch ligand DLL4 precursor; XDLL-4. 

浓    度  1mg/1ml 

规 格  0.1ml/100μg  0.2ml/200μg          

抗体来源  Rabbit  

克隆类型  polyclonal 

交叉反应  Human, Mouse, Rat, Dog, Pig, Cow, Horse   

产品类型  一抗    

研究领域  细胞生物 免疫学 神经生物学 细胞周期蛋白 细胞膜受体  

蛋白分子量  predicted molecular weight: 72kDa 

性    状  Lyophilized or Liquid 

免 疫 原  KLH conjugated synthetic peptide derived from human DLL4 

亚    型  IgG 

纯化方法  affinity purified by Protein A 

储 存 液  0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide 

产品应用   WB=1:100-500  ELISA=1:500-1000  IP=1:20-100  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500 

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

Notch信号通路Delta样配体4抗体产品介绍 The LIN-12/Notch family of transmembrane receptors is believed to play a central role in development by regulating cell fate decisions. Notch proteins have been found to be overexpressed or rearranged in human tumors. Ligands for Notch include Jagged, Jagged-2 and Delta. While blocking the differentiation of progenitor cells into the B-cell lineage, Delta promotes the emergence of a population of cells with T cell/NK-cell characteristics. The protein is a membrane protein expressed in heart, pancreas, brain and muscle during gastrulation and early organogenesis and in adult heart and lung. Delta-4 is a membrane protein that activates Notch-1 and Notch-4. It is expressed in a wide range of adult and fetal tissues, especially in vascular endothelium.

Function : Plays a role in the Notch signaling pathway. Activates Notch-1 and Notch-4.

Subunit : Binds to Notch-1 and Notch-4 (By similarity).

Subcellular Location : Membrane; Single-pass type I membrane protein (Probable).

Tissue Specificity : Expressed in vascular endothelium.

Post-translational modifications : Ubiquitinated by MIB (MIB1 or MIB2), leading to its endocytosis and subsequent degradation.

Similarity : Contains 1 DSL domain.

Contains 8 EGF-like domains.

Database links : UniProtKB/Swiss-Prot: Q9NR61.1