Anti- WT-1/Wilms Tumor Protein蛋白抗体
From:ABCAM
Catalog Number :RS- 6983R
Quantity size : 0.1ml (dilute with pH 7.4 0.01 M PBS or antibody diluent ) Background: Transcription factor that plays an important role in cellular development and cell survival. Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. Recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3'. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors. Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing. Isoform 1 has lower affinity for DNA, and can bind RNA.
Subunit : Homodimer. Interacts with WTIP. Interacts with actively translating polysomes. Detected in nuclear ribonucleoprotein (mRNP) particles. Interacts with HNRNPU via the zinc-finger region. Interacts with U2AF2. Interacts with CITED2. Interacts with ZNF224 via the zinc-finger region. Interacts with WTAP and SRY. Interacts with FAM123B/WTX. Interacts with RBM4.
Subcellular Location : Nucleus. Nucleus, nucleolus. Cytoplasm. Note=Shuttles between nucleus and cytoplasm.Anti- WT-1/Wilms Tumor Protein蛋白抗体Isoform 1: Nucleus speckle.
Isoform 4: Nucleus, nucleoplasm.
Tissue Specificity : Expressed in the kidney and a subset of hematopoietic cells.
Similarity : Belongs to the EGR C2H2-type zinc-finger protein family.
Contains 4 C2H2-type zinc fingers.
Specificity : Anti- WT-1/Wilms Tumor Protein is a rabbit polyclonal antibody
specific for WT-1/Wilms Tumor Protein of Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Sheep,
use for western blotting,elisa,immunoprecipitation and immunohistochemistry
– Protein G affinity chromatography purification, purity :>95%
– Isotype: IgG
– mol wt: 55kDa
Application :
– WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200
– KLH conjugated synthetic peptide derived from human Wilms Tumor Protein
– not yet tested in other applications.
– optimal dilutions/concentrations should be determined by the end user..
Storage: Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20℃. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody, the antibody is stable for at least six weeks at 2-4 ℃
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Anti- WT-1/Wilms Tumor Protein蛋白抗体
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