In Situ Probing of IgG Conjugated Gold Nanoparticles in Liquids by SEM and ToFSIMS

2019-07-23 14:13  下载量：0

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We report recent results of in situ observations of IgG conjugated gold nanoparticles in a novel portable vacuum compatible microfluidic device using scanning electron microscope (SEM) and time-of-flight secondary ion mass spectrometry (ToF-SIMS). The unique feature of the liquid flow cell is that the detection window is open to the vacuum allowing direct probing of the liquid surface. The liquid is held within the aperture by the surface tension. The flow cell is composed of a silicon nitride (SiN) membrane and polydimethylsiloxane (PDMS). We have demonstrated that it is fully compatible with vacuum operations for surface analysis. The aperture can be drilled through the 100 nm SiN using a SEM focused ion beam (FIB) or the primary ion beam in ToF-SIMS. Characteristic signals of the conjugated gold nanoparticles were successfully observed through the aperture by both energydispersive X-ray spectroscopy (EDX) in SEM and ToF-SIMS.

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天津多为莱博科技有限公司
铜牌会员 | 第6年
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