E3 ligase Ligand 1

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产品名称：E3 ligase Ligand 1

产品别名：见爱必信官网

英文别名：E3 ligase Ligand 1

靶点：E3 Ligand Plus Linker (VH032)

CAS：1948273-03-7

纯度：98%

外观：见爱必信官网

保存方法：store at -20℃ for one year（Powder）

描述：E3 ligase Ligand 1 is a Ligand for E3 Ligase extracted from patent WO/2017/030814A1 compound example 202, used in PROTAC technology.

溶解性：

体外研究：

E3 ligase Ligand 1 is a VHL E3 ligase-binding ligand. E3 ligase Ligand 1 is used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC. ARV-771, a small-molecule pan-BET degrader based on proteolysis-targeting chimera (PROTAC) technology, demonstrates dramatically improved efficacy in cellular models of castration-resistant prostate cancer (CRPC) as compared with BET inhibition.

体内研究：E3 ligase Ligand 1 is a VHL E3 ligase-binding ligand. E3 ligase Ligand 1 is used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC. ARV-771, a small-molecule pan-BET degrader based on proteolysis-targeting chimera (PROTAC) technology, demonstrates dramatically improved efficacy in cellular models of castration-resistant prostate cancer (CRPC) as compared with BET inhibition.

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