供货周期: | 7天 |
品牌: | 爱必信 |
型号: | 98% |
货号: | abs821388 |
CAS号: | 1948273-03-7 |
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抑制剂描述: 产品名称:E3 ligase Ligand 1 产品别名:见爱必信官网 英文别名:E3 ligase Ligand 1 靶点:E3 Ligand Plus Linker (VH032) CAS:1948273-03-7 纯度:98% 外观:见爱必信官网 保存方法:store at -20℃ for one year(Powder) 描述:E3 ligase Ligand 1 is a Ligand for E3 Ligase extracted from patent WO/2017/030814A1 compound example 202, used in PROTAC technology. 溶解性: 体外研究: E3 ligase Ligand 1 is a VHL E3 ligase-binding ligand. E3 ligase Ligand 1 is used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC. ARV-771, a small-molecule pan-BET degrader based on proteolysis-targeting chimera (PROTAC) technology, demonstrates dramatically improved efficacy in cellular models of castration-resistant prostate cancer (CRPC) as compared with BET inhibition. 体内研究:E3 ligase Ligand 1 is a VHL E3 ligase-binding ligand. E3 ligase Ligand 1 is used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC. ARV-771, a small-molecule pan-BET degrader based on proteolysis-targeting chimera (PROTAC) technology, demonstrates dramatically improved efficacy in cellular models of castration-resistant prostate cancer (CRPC) as compared with BET inhibition.
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