GDC-0575|＞98%|abs814659-爱必信(上海)生物科技有限公司

GDC-0575

参考价：¥2048

供货周期：

一周

品牌：

爱必信

规格：

＞98%

货号：

abs814659

CAS号：

1196541-47-5

产品详情

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抑制剂描述：

产品名称：GDC-0575

产品别名：见爱必信官网

英文别名：GDC-0575

靶点：Chk

CAS：1196541-47-5

纯度：＞98%

外观：见爱必信官网

保存方法：Store at -20°C

描述：

GDC-0575 (ARRY-575, RG7741) is a potent and selective CHK1 inhibitor with an IC50 of 1.2?nM.

溶解性：DMSO ：75 mg/mL (198.27 mM)
Ethanol :5 mg/mL (13.22 mM)

体外研究：

GDC-0575 is significantly more potent in promoting DNA damage, replication stress and cell death than V158411, LY2603618, and MK-8776 in a panel of melanoma cell lines. GDC-0575 abrogates DNA damage-induced S and G2–M checkpoints, exacerbates DNA double-strand breaks and induces apoptosis in STS cells. GDC-0575 has a synergistic or additive effect together with gemcitabine. CHK1 inhibitor GDC-0575 in combination with AraC enhances the killing of primary acute myeloid leukemia cells ex vivo by inducing apoptosis.

体内研究：GDC-0575 is active at 25 mg/kg as a single agent, but the efficacy is improved at the higher drug dose. GDC-0575 effectively blocks tumor growth in the D20 and C002 xenografts, and the effect is maintained for at least 10 days after the final dose is administered.

产品信息订购：

产品货号	产品名称	规格	价格	大包装及货期
abs814659	GDC-0575	5mg	2048.00	立即咨询
abs814659	GDC-0575	25mg	6038.00	立即咨询

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