供货周期: | 一周 |
品牌: | 爱必信 |
规格: | |
货号: | abs820404 |
CAS号: | 1234015-57-6 |
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抑制剂描述: 产品名称:Prexasertib Mesylate Hydrate 产品别名:见爱必信官网 英文别名:Prexasertib Mesylate Hydrate 靶点:Chk CAS:1234015-57-6 纯度: 外观:见爱必信官网 保存方法:store at -20℃ for one year(Powder) 描述:Prexasertib Mesylate Hydrate (LY2606368 Mesylate Hydrate) is a potent, selective, ATP competitive CHK1 and CHK2 inhibitor, with a Ki of 0.9 nM for CHK1 and IC50s of 50 of 9 nM. 溶解性:10 mM in DMSO 体外研究: Prexasertib Mesylate Hydrate (LY2606368 Mesylate Hydrate) is an ATP competitive CHK1 inhibitor, with a Ki of 0.9 nM and an IC50 of .Prexasertib (LY2606368) shows high anti-tumor activity against U-2 OS, Calu-6 and HeLa cells (IC50, 3, 3, 37 nM, respectively), causes DNA damage during S-phase requiring CDC25A and CDK2 at 4 μM.Prexasertib (0-20 nM) synergizes with olaparib (0-20 μM) to decrease cell viability in HGSOC cells. 体内研究:Prexasertib Mesylate Hydrate (LY2606368 Mesylate Hydrate) is an ATP competitive CHK1 inhibitor, with a Ki of 0.9 nM and an IC50 of .Prexasertib (LY2606368) shows high anti-tumor activity against U-2 OS, Calu-6 and HeLa cells (IC50, 3, 3, 37 nM, respectively), causes DNA damage during S-phase requiring CDC25A and CDK2 at 4 μM.Prexasertib (0-20 nM) synergizes with olaparib (0-20 μM) to decrease cell viability in HGSOC cells.
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