GDC-0575 dihydrochloride|98%|abs821099-爱必信(上海)生物科技有限公司

GDC-0575 dihydrochloride

参考价：¥2646

供货周期：

一周

品牌：

爱必信

规格：

98%

货号：

abs821099

CAS号：

1657014-42-0

产品详情

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抑制剂描述：

产品名称：GDC-0575 dihydrochloride

产品别名：见爱必信官网

英文别名：GDC-0575 dihydrochloride

靶点：Chk

CAS：1657014-42-0

纯度：98%

外观：见爱必信官网

保存方法：store at -20℃ for one year（Powder）

描述：GDC-0575 dihydrochloride is an orally bioavailable CHK1 inhibitor, with an IC50 of 1.2 nM, and has antitumor activity.

溶解性：

体外研究：

GDC-0575 dihydrochloride is a selective and orally bioavailable CHK1 inhibitor, with an IC50 of 1.2 nM. GDC-0575 (100 nM) suppressses CHK1 activation induced by AraC by decreasing the level of Tyr15-phosphorylated CDK2. GDC-0575 (100 nM) has no effect on the viability of AML cells, but significantly reduces cell viability and induces apoptosis in combination with AraC. In addition, GDC-0575 plus AraC shows no effect on normal hematopoietic stem and progenitor cells (HSPCs). GDC-0575 shows cytotoxic activity against most of 20 melanoma cell lines tested, but several cell lines grown as tumour sphere (TS) are relatively insensitive.

体内研究：GDC-0575 dihydrochloride is a selective and orally bioavailable CHK1 inhibitor, with an IC50 of 1.2 nM. GDC-0575 (100 nM) suppressses CHK1 activation induced by AraC by decreasing the level of Tyr15-phosphorylated CDK2. GDC-0575 (100 nM) has no effect on the viability of AML cells, but significantly reduces cell viability and induces apoptosis in combination with AraC. In addition, GDC-0575 plus AraC shows no effect on normal hematopoietic stem and progenitor cells (HSPCs). GDC-0575 shows cytotoxic activity against most of 20 melanoma cell lines tested, but several cell lines grown as tumour sphere (TS) are relatively insensitive.

产品信息订购：

产品货号	产品名称	规格	价格	大包装及货期
abs821099	GDC-0575 dihydrochloride	5mg	2646.00	立即咨询
abs821099	GDC-0575 dihydrochloride	25mg	7686.00	立即咨询

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