4EGI-1|>98%|abs813459-爱必信(上海)生物科技有限公司

4EGI-1

参考价：¥1311

供货周期：

一周

品牌：

爱必信

规格：

>98%

货号：

abs813459

CAS号：

315706-13-9

产品详情

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抑制剂描述：

产品名称：4EGI-1

产品别名：见爱必信官网

英文别名：4EGI-1

靶点：eIF

CAS：315706-13-9

纯度：>98%

外观：见爱必信官网

保存方法：store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.

描述：

4EGI-1 is a competitive eIF4E/eIF4G interaction inhibitor by binding to eIF4E with K_D of 25 μM.

溶解性：DMSO ：45.1 mg/mL (100 mM)

体外研究：

4EGI-1 is an inhibitor of eIF4E/eIF4G interaction, with a Kd of 25 μM against eIF4E binding. 4EGI-1 disrupts the eIF4F complex and inhibits expression of oncogenic proteins in mammalian cells. 4EGI-1 (0-40 μM) also exhibits proapoptotic activity and inhibits the growth of multiple cancer cell lines. 4EGI-1 is cytotoxic to breast cancer cells, such as SKBR-3, MCF-7 and MDA-MB-231 cells, with the IC50 of appr 30 μM, and to the non-CSCs (Cancer stem cells), the IC50 is about 22 μM. 4EGI-1 enhances breast CSC differentiation (40 μM), and suppresses breast CSC induced HUVEC tube-like structure formation (8 μM). Moreover, 4EGI-1 selectively inhibits translation that persists in CSC maintenance and dissemination. 4EGI-1 (50 μM) impairs the formation of eIF4F complex in U87 cells. 4EGI-1 (10, 50 and 100 μM) inhibits cell proliferation via inducing apoptosis in U87 cells, and the apoptosis is via Bax activation. 4EGI-1 causes mitochondrial dysfunction, and induces ER stress via GRP-78 activation, in U87 cells.

体内研究：4EGI-1 (75 mg/kg, i.p.) inhibits breast cancer stem cells (CSC) tumor growth and tumorangiogenesis in vivo. 4EGI-1 (75 mg/kg, i.p.) shows inhibitory effect on the tumor volume and weight in mice bearing U87 cells.

产品信息订购：

产品货号	产品名称	规格	价格	大包装及货期
abs813459	4EGI-1	10mg	1311.00	立即咨询
abs813459	4EGI-1	25mg	2391.00	立即咨询
abs813459	4EGI-1	50mg	3471.00	立即咨询
abs813459	4EGI-1	5mg	1007.00	立即咨询

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