供货周期: | 一周 |
品牌: | 爱必信 |
规格: | |
货号: | abs818316 |
CAS号: | 432499-63-3 |
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抑制剂描述: 产品名称:4E2RCat 产品别名:见爱必信官网 英文别名:4E2RCat 靶点:eif CAS:432499-63-3 纯度: 外观:见爱必信官网 保存方法: 描述:4E2RCat is an inhibitor of eIF4E-eIF4G interaction with an IC50 of 13.5 μM. 溶解性:DMSO: 15.5 mg/mL 体外研究: 4E2RCat prevents the interaction between eIF4E (the cap-binding protein) and eIF4G (a large scaffolding protein), inhibiting cap-dependent translation. It significantly decreases human coronavirus 229E (HCoV-229E) replication, reducing the percentage of infected cells and intra- and extracellular infectious virus titers. 4E2RCat inhibits cap-dependent translation in a dose-dependent manner. 4E2RCat inhibits cap-dependent FF translation but not EMCV IRES-driven Ren translation. 4E2RCat inhibits coronavirus replication in a dose- and time-dependent manner. 体内研究:4E2RCat inhibits protein synthesis in vivo and it is not a consequence of increased cell death.
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