供货周期: | 一周 |
品牌: | 爱必信 |
规格: | 98% |
货号: | abs823174 |
CAS号: | 2095677-20-4 |
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抑制剂描述: 产品名称:eIF4A3-IN-2 产品别名:见爱必信官网 英文别名:eIF4A3-IN-2 靶点:eif;Autophagy CAS:2095677-20-4 纯度:98% 外观:见爱必信官网 保存方法:store at -20℃ for one year(Powder) 描述: eIF4A3-IN-2 is a highly selective and noncompetitive eukaryotic initiation factor 4A-3 (eIF4A3) inhibitor with an IC50 of 110 nM. 溶解性:In Vitro: DMSO : 100 mg/mL (165.92 mM; Need ultrasonic) 体外研究: eIF4A3-IN-2 (compound 2) binds to the allosteric region in eIF4A3 and inhibits in vitro ATPase, helicase, and cellular nonsense-mediated RNA decay (NMD) activities.Apoptosis AnalysisCell Line:HEK293T cells (transfected with the NMD reporter) luciferase assayConcentration:0.3, 1, 3, or 10 μMIncubation Time:3 or 6 hResult:eIF4A3-IN-2 induces an approximately 3.2-fold increase in luciferase activity, indicating that NMD is inhibited by compound 2. 体内研究:
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