供货周期: | 一周 |
品牌: | 爱必信 |
规格: | >98% |
货号: | abs812255 |
CAS号: | 1432908-05-8 |
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抑制剂描述: 产品名称:FRAX1036 产品别名:见爱必信官网 英文别名:FRAX1036 靶点:PAK CAS:1432908-05-8 纯度:>98% 外观:见爱必信官网 保存方法:store at -20℃ for one year(Powder); in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months. 描述: FRAX1036是新型ATP竞争性的PAK小分子抑制剂。 溶解性:DMSO : 5.3 mg/mL (Need warming) 体外研究: Potent cellular inhibition of group I PAK substrate phosphorylation (MEK1-S298 and CRAF-S338) was observed at 2.5 to 5 μM concentrations of FRAX1036 in PAK1-amplified MDA-MB-175 cells. Treatment of PAK1-amplified breast cancer cells with FRAX1036 results in apoptosis. And treatment of OVCAR-3 cells with FRAX-1036 results in upregulation of p53 and p21, while down-regulating cyclin B1. 体内研究:Treatment with Frax1036 results in slower KT21 tumor growth and is unlikely to have significant blood brain barrier permeability in mice.
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