NVS-PAK1-1|98%|abs821186-爱必信(上海)生物科技有限公司

NVS-PAK1-1

参考价：¥1386

供货周期：

一周

品牌：

爱必信

规格：

98%

货号：

abs821186

CAS号：

1783816-74-9

产品详情

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抑制剂描述：

产品名称：NVS-PAK1-1

产品别名：见爱必信官网

英文别名：NVS-PAK1-1

靶点：PAK

CAS：1783816-74-9

纯度：98%

外观：见爱必信官网

保存方法：store at -20℃ for one year（Powder）

描述：

NVS-PAK1-1 is a potent and selective allosteric PAK1 inhibitor with an IC50 of 5 nM.

溶解性：DMSO : ≥ 125 mg/mL (260.45 mM)

体外研究：

NVS-PAK1-1 demonstrates high selectivity for inhibition of PAK1 over other PAK isoforms and the kinome in general. NVS-PAK1-1 has a biochemical PAK1 Kd of 7 nM and a PAK2 Kd of 400 nM. NVS-PAK1-1 shows excellent activity in biochemical assays and an exceptional selectivity profile against other known kinases. NVS-PAK1-1 at 6-20 μM inhibits the phosphorylation of the downstream substrate MEK1 Ser289. Consistent with the observation, NVS-PAK1-1 inhibits proliferation of Su86.86 cell line only above a concentration of 2 μM. In contrast, by applying a mixture of NVS-PAK1-1 and PAK2 shRNA, inhibition of downstream signaling and cell proliferation at a significantly lower 0.21 μM concentration are achieved.

体内研究：NVS-PAK1-1 demonstrates high selectivity for inhibition of PAK1 over other PAK isoforms and the kinome in general. NVS-PAK1-1 has a biochemical PAK1 Kd of 7 nM and a PAK2 Kd of 400 nM. NVS-PAK1-1 shows excellent activity in biochemical assays and an exceptional selectivity profile against other known kinases. NVS-PAK1-1 at 6-20 μM inhibits the phosphorylation of the downstream substrate MEK1 Ser289. Consistent with the observation, NVS-PAK1-1 inhibits proliferation of Su86.86 cell line only above a concentration of 2 μM. In contrast, by applying a mixture of NVS-PAK1-1 and PAK2 shRNA, inhibition of downstream signaling and cell proliferation at a significantly lower 0.21 μM concentration are achieved.

产品信息订购：

产品货号	产品名称	规格	价格	大包装及货期
abs821186	NVS-PAK1-1	5mg	1386.00	立即咨询
abs821186	NVS-PAK1-1	25mg	5355.00	立即咨询

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