供货周期: | 一周 |
品牌: | 爱必信 |
规格: | >98% |
货号: | abs810668 |
CAS号: | 244240-24-2 |
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抑制剂描述: 产品名称:LFM-A13 产品别名:见爱必信官网 英文别名:LFM-A13 靶点:PLK CAS:244240-24-2 纯度:>98% 外观:见爱必信官网 保存方法:store at -20℃ for one year(Powder); in DMSO or others solvent store at 2-4℃ for two weeks, at -80℃ for six months. 描述:FM-A13 is a selective inhibitor of Bruton’s tyrosine kinase (BTK) – IC??’s = 2.5 μM (recombinant BTK) and 17.2 μM (human BTK). 溶解性:DMSO 72 mg/mL warmed (200.0 mM) 体外研究: In BTK+ B-lineage leukemic cells, LFM-A13 enhances their sensitivity to ceramide- or vincristine-induced apoptosis. In BCL-1 cells, NALM-6 cells, or normal BALB/c splenocytes, LFM-13 inhibits the enzymatic activity of BTK in BCL-1 cells without affecting the BTK protein expression levels In human neutrophils, LFM-A13 decreases the tyrosine phosphorylation induced by fMet-Leu-Phe and inhibits the production of superoxide anions and the stimulation of adhesion, chemotaxis, and phospholipase D activity. 体内研究:In BALB/c mice bearing BCL-1 leukemia, combination of LFM-A13 (50 mg/kg/day i.p.) and the standard triple-drug VPL prolongs the median survival time. In primary myeloma-bearing SCID-rab mice, LFM-A13 inhibits osteoclast activity, prevents myeloma-induced bone resorption and suppresss myeloma growth.
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