供货周期: | 一周 |
品牌: | 爱必信 |
规格: | 98% |
货号: | abs817462 |
CAS号: | 1052532-15-6 |
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抑制剂描述: 产品名称:SBE 13 HCl 产品别名:见爱必信官网 英文别名:SBE 13 HCl 靶点:PLK CAS:1052532-15-6 纯度:98% 外观:见爱必信官网 保存方法:store at -20℃ for one year(Powder); in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months. 描述:SBE13 hydrochloride is a potent and selective PLK1 with IC50 of 0.2 nM; no inhibition om Aurora A kinase, Plk2 and Plk3. 溶解性:10 mM in water;100 mM in DMSO; 10 mM in ethanol 体外研究: SBE 13 decreases cell proliferation in various cancer cell lines, and causes a G2/M arrest followed by apoptosis. In primary cells, SBE 13 does not impair cell cycle and thus proliferation of primary cells. SBE13 in combination with Enzastaurin displays a synergistic reduction of cell proliferation and enhanced apoptosis induction in HCT116(p53-/-) cells. 体内研究:
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