供货周期: | 一周 |
品牌: | 爱必信 |
规格: | >98% |
货号: | abs814008 |
CAS号: | 1798871-31-4 |
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抑制剂描述: 产品名称:Centrinone-B 产品别名:见爱必信官网 英文别名:Centrinone-B 靶点:PLK CAS:1798871-31-4 纯度:>98% 外观:见爱必信官网 保存方法:store at -20℃ for one year(Powder); in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months. 描述:Centrinone-B is a high affinity and selective PLK4 inhibitor (Ki = 0.59 nM). 溶解性: 体外研究: Centrinone-B is a potent and highly selective PLK4 inhibitor, with a Ki of 0.59 nM. Centrinone-B slightly binds to Aurora A and Aurora B, with Kis of 1239 nM and 5597.14 nM. Centrinone B exhibits >1000-fold selectivity for Plk4 over Aurora A/B in vitro and does not affect cellular Aurora A or B substrate phosphorylation at concentrations that deplete centrosomes. Centrinone B (0-200 nM) significantly decreases cell viability of PLK4-centriole conjunction melanoma cell lines except p53 mutant SK-MEL-28, and this effect is via inhibition of PLK4. Inhibition of PLK4 by Centrinone B also induces apoptosis in human melanoma cell lines. 体内研究:
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