Centrinone-B|>98%|abs814008-爱必信(上海)生物科技有限公司

Centrinone-B

参考价：¥2756

供货周期：

一周

品牌：

爱必信

规格：

>98%

货号：

abs814008

CAS号：

1798871-31-4

产品详情

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抑制剂描述：

产品名称：Centrinone-B

产品别名：见爱必信官网

英文别名：Centrinone-B

靶点：PLK

CAS：1798871-31-4

纯度：>98%

外观：见爱必信官网

保存方法：store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.

描述：Centrinone-B is a high affinity and selective PLK4 inhibitor (Ki = 0.59 nM).

溶解性：

体外研究：

Centrinone-B is a potent and highly selective PLK4 inhibitor, with a Ki of 0.59 nM. Centrinone-B slightly binds to Aurora A and Aurora B, with Kis of 1239 nM and 5597.14 nM. Centrinone B exhibits >1000-fold selectivity for Plk4 over Aurora A/B in vitro and does not affect cellular Aurora A or B substrate phosphorylation at concentrations that deplete centrosomes. Centrinone B (0-200 nM) significantly decreases cell viability of PLK4-centriole conjunction melanoma cell lines except p53 mutant SK-MEL-28, and this effect is via inhibition of PLK4. Inhibition of PLK4 by Centrinone B also induces apoptosis in human melanoma cell lines.

体内研究：

产品信息订购：

产品货号	产品名称	规格	价格	大包装及货期
abs814008	Centrinone-B	50mg	2756.00	立即咨询
abs814008	Centrinone-B	100mg	4410.00	立即咨询

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