供货周期: | 7天 |
品牌: | 爱必信 |
型号: | >98% |
货号: | abs810115 |
CAS号: | 312756-74-4 |
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抑制剂描述: 产品名称:RS-1 产品别名:见爱必信官网 英文别名:RS-1 靶点:RAD51 CAS:312756-74-4 纯度:>98% 外观:见爱必信官网 保存方法:store at -20℃ for one year(Powder); in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months. 描述: RS-1 is a stimulator of the human homologous recombination protein RAD51,enhances homology-directed repair ~2 to 5-fold and increases CRISPR-mediated knock-in efficiencies in vitro and in vivo. 溶解性:DMSO : 52.4 mg/mL (100 mM) 体外研究: RS-1 stimulates the binding of hRAD51 to ssDNA. Low-micromolar concentrations of this small molecule enhance DNA binding and result in longer protein–DNA complex lengths. In addition, RS-1 stabilizes the active form of hRAD51 filaments and this is reflected in an enhanced strand assimilation activity. RS-1 enhances Cas9- and TALEN-mediated knock-in efficiency in rabbit embryos both in vitro and in vivo. 体内研究:
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