Zoledronic acid

Zoledronic acid

参考价:¥868
供货周期: 一周
品牌: 爱必信
规格: >98%
货号: abs813447
CAS号: 118072-93-8
爱必信(上海)生物科技有限公司
银牌会员2年生产商
关注展位 全部试剂
产品详情

公告提醒:爱必信所有产品和服务仅用于科学研究不用于临床应用及其他用途提供产品和服务也不为任何个人提供产品和服务)!

 

抑制剂描述:

产品名称:Zoledronic acid

产品别名:见爱必信官网

英文别名:Zoledronic acid

靶点:Rho

CAS:118072-93-8

纯度:>98%

外观:见爱必信官网

保存方法:store at -20℃ for one year(Powder); in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.

描述:

Zoledronic Acid 是一种有效的含氮双膦酸盐,抑制人胎儿成骨细胞(hFOB)增殖,IC50为40 μM。

溶解性:1.1eq. NaOH :13.6 mg/mL (50 mM)
Water :0.7 mg/mL (2.5 mM)

体外研究:

Zoledronic acid (10 μM and 100 μM) causes a significant reduction in the proportions of MCF-7 cells (49.54% and 23.55% of control, respectively) (P Zoledronic acid enhances OPG gene expression and protein secretion by human osteoblasts (hOB) in a dose-dependent fashion with a maximum effect at 10 nM after 72 hours, consistent with the higher biological potency of Zoledronic acid. Zoledronic acid prevents the inhibitory effects of the glucocorticoid dexamethasone on OPG mRNA and protein production in human osteoblasts. Zoledronic acid induces type I collagen secretion and alkaline phosphatase activity by 2- and 4-fold, respectively, in human osteoblasts.

体内研究:Zoledronic acid (120 mg/kg, s.c.) prevents the formation of lesions, prevents cancellous bone loss and loss of bone mineral density, and reduces osteoclast perimeter in 5T2MM-bearing mice. Zoledronic acid (120 mg/kg, s.c.) also decreases paraprotein concentration, decreases tumor burden, and reduces angiogenesis in 5T2MM-bearing mice.

产品信息订购:

  产品货号   产品名称   规格 价格 大包装及货期
  abs813447   Zoledronic acid   50mg   868.00   立即咨询
  abs813447   Zoledronic acid   100mg   1571.00   立即咨询
  abs813447   Zoledronic acid   200mg   2166.00   立即咨询
  abs813447   Zoledronic acid   25mg   536.00   立即咨询

产品更多信息请进入爱必信网站咨询

相关产品

同类推荐 更多
Zoledronic acid由爱必信(上海)生物科技有限公司为您提供,货号abs813447,规格:>98%,CAS号:118072-93-8,如您想了解更多关于Zoledronic acid价格、Zoledronic acid结构式、批发、用途等信息,欢迎咨询。除供应Zoledronic acid外,还可为您提供其他等试剂,公司有专业的客户服务团队,是您值得信赖的合作伙伴,爱必信客户服务电话,售前、售后均可联系。
Business information
工商信息 信息已认证
contact us
联系方式

详细地址

上海市浦东新区新浩路58号18号楼
当前位置: 爱必信 试剂 Zoledronic acid

关注

拨打电话

留言咨询