供货周期: | 一周 |
品牌: | 爱必信 |
规格: | >98% |
货号: | abs811969 |
CAS号: | 71486-22-1 |
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抑制剂描述: 产品名称:Vinorelbine 产品别名:见爱必信官网 英文别名:Vinorelbine 靶点:Alkaloids CAS:71486-22-1 纯度:>98% 外观:见爱必信官网 保存方法:Store at -20°C 描述: Vinorelbine is a semisynthetic vinca alkaloid. Vinorelbine binds to tubulin and prevents the formation of the mitotic spindle, resulting in the arrest of tumor cell growth in metaphase. 溶解性:DMSO : 100 mg/mL 体外研究: Vinorelbine (0.5-5 nM) inhibits cell proliferation by 50% (IC50) at concentrations of 1.25 nM. At concentration of 8 nM vinorelbine, no cells are in anaphase. Vinorelbine time-dependently induces the p53 and p21WAFI/CIP1 expression in androgen-dependent (AD) and- independent (AI) prostate cancer cell lines. Vinorelbine stimulates reporter genes in a concentration-dependent manner. 体内研究:After vinorelbine treatment, the first neutropenicepisode occurred after the first (4 dogs), second (1), or sixth(1) vinorelbine treatment in the dogs. Vinorelbine is tolerated at a weekly interval in tumor-bearing cats, with an MTD of 11.5 mg/m2.
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