供货周期: | 一周 |
品牌: | 爱必信 |
规格: | 99.14 % |
货号: | abs816038 |
CAS号: | 481-49-2 |
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抑制剂描述: 产品名称:Cepharanthine 产品别名:见爱必信官网 英文别名:Cepharanthine 靶点:Alkaloids CAS:481-49-2 纯度:99.14 % 外观:见爱必信官网 保存方法:store at -20℃ for one year(Powder); in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months. 描述: Cepharanthine is a biscoclaurine alkaloid inhibiting tumor necrosis factor (TNF)-α-mediated NFκB stimulation, plasma membrane lipid peroxidation and platelet aggregation and suppressing cytokine production. 溶解性:体外: 体外研究: Treatment of SaOS2 cells with Cepharanthine (CEP) (2.5-20 μmol/L) inhibits the cell growth in a concentration- and time-dependent manner. CEP (10 μmol/L) caused cell cycle arrest at G(1) phase and induced apoptosis of SaOS2 cells. CEP (10 and 15 μmol/L) significantly decreases the expression of STAT3 in SaOS2 cells. Furthermore, CEP (5 and 10 μmol/L) significantly inhibits the expression of target genes of STAT3, including the anti-apoptotic gene Bcl-xL and the cell cycle regulators c-Myc and cyclin D1. 体内研究:In nude mouse xenografts of SaOS2 cells, Cepharanthine (CEP) (20 mg?kg(-1)?d(-1), ip for 19 d) significantly reduces the volume and weight of the tumor.
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