| 供货周期： | 一周 |
| 品牌： | 爱必信 |
| 规格： | 99.14 % |
| 货号： | abs816038 |
| CAS号： | 481-49-2 |
| 公告提醒：爱必信所有产品和服务仅用于科学研究，不用于临床应用及其他用途提供产品和服务（也不为任何个人提供产品和服务）!
抑制剂描述： 产品名称：Cepharanthine 产品别名：见爱必信官网 英文别名：Cepharanthine 靶点：Alkaloids CAS：481-49-2 纯度：99.14 % 外观：见爱必信官网 保存方法：store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months. 描述： Cepharanthine is a biscoclaurine alkaloid inhibiting tumor necrosis factor (TNF)-α-mediated NFκB stimulation, plasma membrane lipid peroxidation and platelet aggregation and suppressing cytokine production. 溶解性：体外: 体外研究： Treatment of SaOS2 cells with Cepharanthine (CEP) (2.5-20 μmol/L) inhibits the cell growth in a concentration- and time-dependent manner. CEP (10 μmol/L) caused cell cycle arrest at G(1) phase and induced apoptosis of SaOS2 cells. CEP (10 and 15 μmol/L) significantly decreases the expression of STAT3 in SaOS2 cells. Furthermore, CEP (5 and 10 μmol/L) significantly inhibits the expression of target genes of STAT3, including the anti-apoptotic gene Bcl-xL and the cell cycle regulators c-Myc and cyclin D1. 体内研究：In nude mouse xenografts of SaOS2 cells, Cepharanthine (CEP) (20 mg?kg(-1)?d(-1), ip for 19 d) significantly reduces the volume and weight of the tumor.
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