供货周期: | 7天 |
品牌: | 爱必信 |
型号: | 98% |
货号: | abs812913 |
CAS号: | 18642-23-4 |
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抑制剂描述: 产品名称:Psoralidin 产品别名:见爱必信官网 英文别名:Psoralidin 靶点:Coumarins CAS:18642-23-4 纯度:98% 外观:见爱必信官网 保存方法:Store at -20° C 描述: Psoralidin inhibits Akt phosphorylation and phosphatidylinositol 3-kinase activation and transcriptionally. Psoralidin possesses anticancer and chemopreventive properties. 溶解性:Soluble in water (partly), and DMSO. 体外研究: Psoralidin has been characterized as a full ER agonist, which activates the classical ER-signaling pathway in both ER-positive human breast and endometrial cell lines as well as non-human cultured cells transiently expressing either ERα or ERβ. Psoralidin was also able to induce the endogenous estrogen-responsive gene, pS2, in human breast cancer cells MCF-7. The IC50 values for psoralidin to replace the binding of E2 to both receptors were 1.03 and 24.6 μM, respectively. Psoralidin is able to bind to both receptors within the micromolar range and has preferential affinity for ERα over ERβ. 体内研究:Acute and subchronic administrations of psoralidin produced a significant reduction in immobility time in the mouse forced swimming test. Psoralidin dose-dependently increased swimming and failed to affect climbing.
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