Daidzin

Daidzin

参考价:¥603
供货周期: 一周
品牌: 爱必信
规格: 99%
货号: abs817656
CAS号: 552-66-9
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抑制剂描述:

产品名称:Daidzin

产品别名:见爱必信官网

英文别名:Daidzin

靶点:Flavonoids

CAS:552-66-9

纯度:99%

外观:见爱必信官网

保存方法:store at -20℃ for one year(Powder); in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.

描述:

Daidzin is an isoflavone that has anti-oxidant, anti-carcinogenic, and anti-atherosclerotic activities; directly inhibits mitochondrial aldehyde dehydrogenase 2 (IC50 = 80 nM) and is an effective anti-dipsotropic isoflavone.

溶解性:DMSO : ≥ 34 mg/mL
Ethanol : 4 mg/mL (9.6 mM)

体外研究:

Daidzin, a glycoside of daidzein, increases the transcriptional activity of RARα and RARγ but does not bind to the RARs. Daidzin does not inhibit human class Ⅰ, Ⅱ, or Ⅲ alcohol dehydrogenases, nor does it have any significant effect on biological systems that are known to be affected by other isoflavones. Daidzin inhibits human ALDH-I and ALDH-II in a concentration-dependent manner. Daidzin inhibits both ALDH-I and ALDH-II in an apparently competitive manner with Ki values of 40 nM and 20 μM, respectively, and it inhibits ALDH-I uncompetitively with respect to NAD+. The inhibition of ALDH-I by daidzin is reversible.

体内研究:Daidzin has no effect on alcohol-metabolizing enzymes(i.e., ADH and ALDH) when given to rats intragastrically. Chronic daidzin administration exerts an effect on alcohol pharmacokinetics, although the effect is less pronounced than when the compound is administered concurrently with ethanol.The compound is shown to shorten sleep time if ethanol is given intragastrically, but not when given intraperitoneally, indicating absence of effect on ethanol elimination rate. Daidzin delays ethanol absorption and lessens alcohol intoxication. The compound is shown to suppress the levels of BAC(blood alcohol concentration) for the first 3 hr after alcohol ingestion in both fasted and fed rats. These effects of daidzin may in part be due to its antioxidant activity.

产品信息订购:

  产品货号   产品名称   规格 价格 大包装及货期
  abs817656   Daidzin   50mg   603.00   立即咨询
  abs817656   Daidzin   200mg   1675.00   立即咨询
  abs817656   Daidzin   25mg   488.00   立即咨询
  abs817656   Daidzin   100mg   965.00   立即咨询

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