Magnolin|＞98%|abs819468-爱必信(上海)生物科技有限公司

Magnolin

参考价：¥630

供货周期：

一周

品牌：

爱必信

规格：

＞98%

货号：

abs819468

CAS号：

31008-18-1

产品详情

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抑制剂描述：

产品名称：Magnolin

产品别名：见爱必信官网

英文别名：Magnolin

靶点：Lignans

CAS：31008-18-1

纯度：＞98%

外观：见爱必信官网

保存方法：Store at -20°C

描述：

Magnolin, a major component of Magnolia flos (Shin-Yi), inhibits the Ras/ERKs/RSK2 signaling axis by targeting the active pocket of ERK1 and ERK2 with IC50s of 87 nM and 16.5 nM, respectively.

溶解性：DMSO : 75 mg/mL (180.1 mM)

体外研究：

Magnolin is a natural compound abundantly found in Magnolia flos, which has been traditionally used in oriental medicine to treat headaches, nasal congestion and anti-inflammatory reactions. Magnolin targets the active pockets of ERK1 and ERK2, which are important signaling molecules in cancer cell metastasis. Magnolin inhibits NF-κB transactivation activity by suppressing the ERKs/RSK2 signaling pathway. Magnolin inhibits the production of tumor necrosis factor-α (TNF-α) and prostaglandin E2 (PGE2) by inhibiting extracellular signal-regulated kinases (ERKs), which are key signaling molecules in the regulation of cell proliferation, transformation and cancer cell metastasis. JB6 Cl41 cell migration enhanced by EGF treatment is dramatically suppressed by Magnolin treatment in a dose-dependent manner. Magnolin inhibits ERK1/2/RSK2 signaling-mediated IκBα phosphorylation at Ser32, resulting in the inhibition of NF-κB activation and cell migration.

体内研究：

产品信息订购：

产品货号	产品名称	规格	价格	大包装及货期
abs819468	Magnolin	10mg	630.00	立即咨询
abs819468	Magnolin	25mg	1103.00	立即咨询

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