| 供货周期： | 一周 |
| 品牌： | 爱必信 |
| 规格： | >98% |
| 货号： | abs813686 |
| CAS号： | 541-46-8 |
| 公告提醒：爱必信所有产品和服务仅用于科学研究，不用于临床应用及其他用途提供产品和服务（也不为任何个人提供产品和服务）!
抑制剂描述： 产品名称：Isovaleramide 产品别名：见爱必信官网 英文别名：Isovaleramide 靶点：Miscellaneous CAS：541-46-8 纯度：>98% 外观：见爱必信官网 保存方法：Store at -20°C 描述： Isovaleramide is an anticonvulsant molecule isolated from Valeriana pavonii, it inhibits the liver alcohol dehydrogenases. 溶解性：Ethanol ：16 mg/mL (158.2 mM) 体外研究： Isovaleramide is isolated from the most active fraction of Valeriana pavonii. Isovaleramide (300 μM) exhibits a 42% of inhibition of the binding of 3H-FNZ to its sites in the in vitro assay. Isovaleramide is without effect at concentrations up to 1000 μM in a variety of in vitro neurotransmitter binding or uptake assays, suggesting that its action does not involve a direct receptor-mediated effect at those systems studied. Isovaleramide (0.15%) induces the formation of nitrile hydratase in Rhodococcus sp. YH 3-3. 体内研究：Isovaleramide (100 mg/Kg, p.o) evidences a 90% index protection against the maximal electroshock seizure in mice (MES). Isovaleramide produces a consistent pattern of signs at relatively high doses in extensive safety studies in rats, rabbits, and dogs. Isovaleramide shows a significantly lower potential for reproductive toxicity than VPA in several reproductive toxicity studies conducted in mice, rats and rabbits.
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