供货周期: | 一周 |
品牌: | 爱必信 |
规格: | 99% |
货号: | abs817688 |
CAS号: | 504-88-1 |
公告提醒:爱必信所有产品和服务仅用于科学研究,不用于临床应用及其他用途提供产品和服务(也不为任何个人提供产品和服务)!
抑制剂描述: 产品名称:Bovinocidin 产品别名:见爱必信官网 英文别名:Bovinocidin 靶点:Miscellaneous CAS:504-88-1 纯度:99% 外观:见爱必信官网 保存方法:store at -20℃ for one year(Powder); in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months. 描述:
Bovinocidin is an irreversible inhibitor of succinate dehydrogenase.
溶解性:DMSO : ≥ 130 mg/mL (1091.70 mM) 体外研究: 3-nitropropionic acid (3-NPA) is an irreversible inhibitor of complex II in the mitochondria. It impairs cellular energy metabolism via inhibition of succinate dehydrogenase, which induces a reduction in ATP production and leads to oxidative stress. 3-NPA can cause the generation and release of ROS from mitochondria, mitochondrial DNA damage, and thus loss of mitochondrial function. 3-NPA reduces the number of large follicles, impairs oocyte development, and increases the percentage of atretic large follicles and ROS levels in oocytes and granulosa cells. ROS production followed by mitochondrial DNA damage is the primary event in 3-NPA toxicity, and Bcl-2 protects PC12 cells from 3-NPA toxicity by preventing mitochondrial DNA damage. 体内研究:3-NPA induces granulosa cell apoptosis, large follicle atresia, and an increase of ROS levels in the ovary.
产品信息订购:
|
相关产品
详细地址
关注
拨打电话
留言咨询