Fumagillin|98%|abs816142-爱必信(上海)生物科技有限公司

Fumagillin

参考价：¥683

供货周期：

一周

品牌：

爱必信

规格：

98%

货号：

abs816142

CAS号：

23110-15-8

产品详情

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抑制剂描述：

产品名称：Fumagillin

产品别名：见爱必信官网

英文别名：Fumagillin

靶点：Miscellaneous

CAS：23110-15-8

纯度：98%

外观：见爱必信官网

保存方法：store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.

描述：

Fumagillin is a selective and potent irreversible inhibitor of Methionine aminopeptidase 2 (<b>MetAP2</b>), used as an antibiotic to treat microsporidiosis.

溶解性：Ethanol : 1.2 mg/mL (2.5 mM)

体外研究：

Fumagillin selectively inhibits the growth of a Δmap1 strain but not a wild-type or a Δmap2 S. cerevisiae strain missing MetAP-2. In budding yeast cells, as a potent inhibitor of angiogenesis, Fumagillin not only reverses the growth inhibitory activity of Vpr, but also inhibits Vpr-dependent viral gene expression upon the infection of human macrophages. Though the toxicity of fumagillin has limited its use for human applications, the analogues using structure-activity relationships relating to its angiogenesis properties may be further explored in the treatment of angiogenesis-dependent diseases.

体内研究：In DEN-treated rats, fumagillin (30 mg/kg, i.p.) inhibits both progression of HCC in the liver itself and systemic metastasis.

产品信息订购：

产品货号	产品名称	规格	价格	大包装及货期
abs816142	Fumagillin	1mg	683.00	立即咨询
abs816142	Fumagillin	5mg	2293.00	立即咨询

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