供货周期: | 一周 |
品牌: | 爱必信 |
规格: | >98% |
货号: | abs817885 |
CAS号: | 579-13-5 |
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抑制剂描述: 产品名称:Oligomycin A 产品别名:见爱必信官网 英文别名:Oligomycin A 靶点:Miscellaneous CAS:579-13-5 纯度:>98% 外观:见爱必信官网 保存方法:store at -20℃ for one year(Powder); in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months. 描述: Oligomycin A是一种ATP synthase抑制剂,作用于线粒体膜的耦合作用,抑制氧化磷酸化和ATP依赖性的反应。 溶解性:DMSO :15 mg/mL (18.96 mM) 体外研究: Oligomycin A is a mitochondrial F0F1-ATPase inhibitor with a Ki of 1 μM. Oligomycin A shows cytotoxic to the NCI-60 cell lines, with GI50 of 10 nM. Oligomycin A also inhibits the activity of Triton X-100-solubilized ATPase with a Ki of 0.1 μM. Furthermore, Oligomycin A has anti-fungal activity. Oligomycin A (2.4?μM) inhibits the ability of spermatozoa to achieve feasible in vitro capacitation (IVC), and also suppresses progesterone-induced in vitro acrosome exocytosis (IVAE) as well as the concomitant peaks of O2 consumption and ATP levels. 体内研究:
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