供货周期: | 一周 |
品牌: | 爱必信 |
规格: | 99% |
货号: | abs817681 |
CAS号: | 481-74-3 |
公告提醒:爱必信所有产品和服务仅用于科学研究,不用于临床应用及其他用途提供产品和服务(也不为任何个人提供产品和服务)!
抑制剂描述: 产品名称:Chrysophanol 产品别名:见爱必信官网 英文别名:Chrysophanol 靶点:Quinones CAS:481-74-3 纯度:99% 外观:见爱必信官网 保存方法:store at -20℃ for one year(Powder); in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months. 描述: Extracted from Rheum palmatum L.;Suitability:Boiling ethanol,benzene,chloroform,ether,acetic acid and acetone;Store the product in sealed,cool and dry condition 溶解性:DMSO : 5 mg/mL (19.66 mM), warmed 体外研究: Chrysophanic acid (Chrysophanol) is a EGFR/mTOR pathway inhibitor. Chrysophanic acid (Chrysophanol) is a natural anthraquinone, has anticancer activity in EGFR-overexpressing SNU-C5 human colon cancer cells. Chrysophanic acid (Chrysophanol) preferentially blocks proliferation in SNU-C5 cells but not in other cell lines (HT7, HT29, KM12C, SW480, HCT116 and SNU-C4) with low levels of EGFR expression. Chrysophanic acid (Chrysophanol) treatment in SNU-C5 cells inhibits EGF-induced phosphorylation of EGFR and suppresses activation of downstream signaling molecules, such as AKT, extracellular signal-regulated kinase (ERK) and the mammalian target of rapamycin (mTOR)/ribosomal protein S6 kinase (p70S6K). Chrysophanic acid also inhibits the replication of poliovirus types 2 and 3 (Picornaviridae) and poliovirus-induced cytopathic effects in BGM (Buffalo green monkey) kidney cells. 体内研究:
产品信息订购:
|
相关产品
详细地址
关注
拨打电话
留言咨询