供货周期: | 一周 |
品牌: | 爱必信 |
规格: | 99% |
货号: | abs817927 |
CAS号: | 550-24-3 |
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抑制剂描述: 产品名称:Embelin 产品别名:见爱必信官网 英文别名:Embelin 靶点:Quinones CAS:550-24-3 纯度:99% 外观:见爱必信官网 保存方法:Store at -20℃ 描述: Embelin,从矮地茶中分离的一种醌类化合物,是一种细胞凋亡的X染色体抑止剂(XIAP)的抑制剂,无细胞试验中IC50为4.1 μM。 溶解性: DMSO 29.4 mg/mL (100 mM) 体外研究: Embelin from the Japanese Ardisia herb is a small-molecular inhibitor that binds to the XIAP BIR3 domain with which Smac and caspsase-9 bind. Embelin inhibits cell growth of both PC-3 and LNCap cells in a dose-dependent manner, with IC50 values of 3.7 and 5.7 μM. While, the toxicity of Embelin in normal PrEC and in WI-38 cells is much lower with IC50 values of 20.1 μM and 19.3 μM. Treatment of PC-3 cells with 25 and 50 μM of embelin for 48 h, 30% and 75% of cells undergo apoptosis, representing approximately 3-and 9-fold increase as compared to untreated cells. Embelin also potently suppresses the biosynthesis of eicosanoids by selective inhibition of 5-lipoxygenase (5-LO) and Microsomal prostaglandin E2 synthase-1 (mPGES-1) with IC50 = 0.06 and 0.2 mM, respectively. 体内研究:
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